{"id":"W2099184601","doi":"10.1093/neuonc/nov061.78","title":"MB-02 * SONIC HEDGEHOG INDUCES YB-1 IN A YAP-DEPENDENT MANNER TO REGULATE Igf2 EXPRESSION AND PROLIFERATION IN CEREBELLAR GRANULE NEURON PROGENITORS AND MEDULLOBLASTOMA CELLS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medulloblastoma; Sonic hedgehog; Biology; Cancer research; Progenitor cell; Cerebellum; Gene knockdown; Oncogene; Granule cell; Cell biology; Stem cell; Cell culture; Cell; Neuroscience; Signal transduction; Hippocampal formation; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004398511,0.000265274,0.0003469111,0.000184909,0.00007147757,0.00003166584,0.0001488918,0.0003231727,0.000001943098],"category_scores_gemma":[0.0002281503,0.0002515683,0.00003070778,0.000156886,0.0001116585,0.00001379009,0.0003609744,0.0002398408,0.000007533868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007085397,"about_ca_system_score_gemma":0.0001748537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003500741,"about_ca_topic_score_gemma":0.0005666654,"domain_scores_codex":[0.9978415,0.0004337404,0.0003894037,0.0007333024,0.0001840957,0.0004179329],"domain_scores_gemma":[0.9992794,0.0000483522,0.0001112799,0.0002561489,0.00008377671,0.000221029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000338485,0.0001301046,0.009239428,0.00002959069,0.000008399878,0.00007844526,0.001190879,0.0002274752,0.9858414,0.0000051065,0.0004929724,0.0024177],"study_design_scores_gemma":[0.001953469,0.002122304,0.00396826,0.00003620609,0.00001421243,0.00007759641,0.0003999173,0.0001300898,0.9799258,0.00006016798,0.01103087,0.0002811639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972922,0.0006166754,0.00002281204,0.0007234343,0.0003828669,0.0007892029,0.000007360322,0.00002107643,0.0001444354],"genre_scores_gemma":[0.9985819,0.0001619762,0.0003029268,0.0005045741,0.0001902121,0.0001481144,0.00001209789,0.00003855673,0.00005963233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105379,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069573786007126,"score_gpt":0.2724929153739531,"score_spread":0.2517971775138819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}