{"id":"W2099184601","doi":"10.1093/neuonc/nov061.78","title":"MB-02 * SONIC HEDGEHOG INDUCES YB-1 IN A YAP-DEPENDENT MANNER TO REGULATE Igf2 EXPRESSION AND PROLIFERATION IN CEREBELLAR GRANULE NEURON PROGENITORS AND MEDULLOBLASTOMA CELLS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medulloblastoma; Sonic hedgehog; Biology; Cancer research; Progenitor cell; Cerebellum; Gene knockdown; Oncogene; Granule cell; Cell biology; Stem cell; Cell culture; Cell; Neuroscience; Signal transduction; Hippocampal formation; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007090686,0.0002509486,0.0001761657,0.000197702,0.0001491234,0.0002062779,0.0001487802,0.0001487312,0.001705865],"category_scores_gemma":[0.00006443558,0.0001587377,0.0002090184,0.0001222421,0.0001502806,0.00009647263,0.0001703725,0.0005319965,0.0006115477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162261,"about_ca_system_score_gemma":0.0002307424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002098532,"about_ca_topic_score_gemma":0.003143882,"domain_scores_codex":[0.9998895,0.000009835067,0.000009907518,0.000022654,0.00003244747,0.00003565732],"domain_scores_gemma":[0.9999415,0.000007891903,0.00001334987,0.00000650708,0.000006063975,0.00002470842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007694298,0.00002750266,0.000144105,0.00002039906,0.000003198143,0.00002911216,0.000008123958,0.00002130421,0.9988206,0.0000609616,0.00008302859,0.0007046313],"study_design_scores_gemma":[0.00002263943,0.0003373005,0.008509185,0.000005520913,0.00001219396,0.0001525284,0.00003551595,0.0008170671,0.9852484,0.00002838194,0.004827945,0.000003365122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923865,0.001630401,0.001799903,0.000161069,0.00005050215,0.00004012763,0.001062856,0.0001550567,0.002713659],"genre_scores_gemma":[0.9860157,0.0007426157,0.001653283,0.00009411757,0.00001335153,0.00007864981,0.002751293,0.0000419552,0.008608933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098532,"threshold_uncertainty_score":0.005706668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069573786007126,"score_gpt":0.2724929153739531,"score_spread":0.2517971775138819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}