{"id":"W2099230922","doi":"10.1128/jb.183.10.2971-2978.2001","title":"Divergence in Fitness and Evolution of Drug Resistance in Experimental Populations of <i>Candida albicans</i>","year":2001,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Pfizer Canada; Pfizer","keywords":"Biology; Candida albicans; Competition (biology); Drug resistance; Experimental evolution; Population; Genetic Fitness; Genotype; Genetics; Fluconazole; Resistance (ecology); Evolutionary biology; Biological evolution; Microbiology; Ecology; Gene; Antifungal; Demography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007675487,0.0004732706,0.0003785697,0.0003307377,0.0004513272,0.0005656953,0.0008795501,0.0006452165,0.0007554063],"category_scores_gemma":[0.001171147,0.0002592615,0.0003974052,0.0003319185,0.0004308948,0.0002974759,0.0006362597,0.001226652,0.0001707213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000892241,"about_ca_system_score_gemma":0.0002763293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001835687,"about_ca_topic_score_gemma":0.002288058,"domain_scores_codex":[0.9988563,0.0003473268,0.0001540892,0.0002809013,0.0002258614,0.0001355254],"domain_scores_gemma":[0.9986583,0.0005146344,0.0002607918,0.0002538859,0.0001419509,0.0001704014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008382961,0.0006659988,0.007512593,0.00008146207,0.00006589454,0.0001094492,0.0001443982,0.001058888,0.9846606,0.0004268246,0.0001501429,0.004285499],"study_design_scores_gemma":[0.0002860747,0.01087666,0.1122781,0.00004581111,0.0001605143,0.001099668,0.0003365942,0.01621348,0.8556442,0.0004722362,0.00244481,0.0001417818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987154,0.0001308205,0.0004538612,0.00002981845,0.00000776465,0.00003204952,0.0001576796,0.00001032135,0.0004623267],"genre_scores_gemma":[0.9928979,0.0001712647,0.004628289,0.0001212577,0.00001711596,0.0001600744,0.001085826,0.00003873077,0.0008795215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835687,"threshold_uncertainty_score":0.00647366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007983716459275555,"score_gpt":0.2584039198788452,"score_spread":0.2504202034195697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}