{"id":"W2099259281","doi":"10.1158/1535-7163.mct-11-0705","title":"Off-Target Function of the Sonic Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide–Dependent Neutral Sphingomyelinase 2/Ceramide Induction","year":2012,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institutes of Health; National Cancer Institute; Rally Foundation","keywords":"Cyclopamine; Ceramide; Biology; Programmed cell death; Gene knockdown; Apoptosis; Cell biology; GLI1; Hedgehog signaling pathway; Smoothened; Cancer research; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008386086,0.0002323354,0.0001860385,0.0001268704,0.00009016915,0.0001891331,0.0001474343,0.0001711619,0.0005264703],"category_scores_gemma":[0.00006821394,0.00007975564,0.0002443912,0.00008963975,0.0001181294,0.0001326422,0.0001282255,0.0002739647,0.0001375943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158306,"about_ca_system_score_gemma":0.0002288625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007058151,"about_ca_topic_score_gemma":0.001537433,"domain_scores_codex":[0.999935,0.000009489841,0.000007385397,0.00001036006,0.0000186714,0.0000190226],"domain_scores_gemma":[0.9999651,0.000006354609,0.000008614478,0.000005340528,0.000005503558,0.000009186923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342092,0.00002540605,0.0001215559,0.00002534405,0.000004292179,0.00003652687,0.000005471764,0.00003990811,0.9982736,0.00005995369,0.00002673008,0.001246935],"study_design_scores_gemma":[0.00001507151,0.0002554823,0.002266379,0.000002610925,0.00001208755,0.0001076393,0.000009545778,0.0005565235,0.9956916,0.00001582911,0.001065371,0.000001897424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954417,0.001445283,0.001032698,0.00006076412,0.00002046187,0.00003027936,0.0002403868,0.00004519833,0.001683279],"genre_scores_gemma":[0.9971896,0.0007563324,0.0008091215,0.00002920291,0.000004261218,0.00002441121,0.0002465571,0.000003865874,0.0009365722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007058151,"threshold_uncertainty_score":0.001761198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767071703615826,"score_gpt":0.256220465018098,"score_spread":0.2385497479819397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}