{"id":"W2099272076","doi":"10.1128/jvi.01084-10","title":"Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Massachusetts Institute of Technology; National Research Foundation; Canadian Institutes of Health Research; Ragon Institute of MGH, MIT and Harvard; Harvard University; Massachusetts General Hospital","keywords":"Biology; Viral replication; Virology; Human leukocyte antigen; Viral load; Group-specific antigen; Epitope; Allele; Genetics; Immunology; Virus; Antibody; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007571757,0.0002304041,0.0002501591,0.0004515787,0.0002499343,0.0005220118,0.0001418373,0.0005443587,0.001526998],"category_scores_gemma":[0.002238564,0.0001420849,0.0001592163,0.0004764099,0.0003823264,0.0003468257,0.0002208214,0.0004437868,0.000285068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501072,"about_ca_system_score_gemma":0.0001862446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004231468,"about_ca_topic_score_gemma":0.0003083722,"domain_scores_codex":[0.9996622,0.0001190407,0.00004341772,0.00006963276,0.00004354054,0.0000622662],"domain_scores_gemma":[0.9973167,0.001127236,0.000822998,0.0001957506,0.0001605193,0.0003769487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005589299,0.00003178958,0.9926238,0.00001046584,0.00003150281,0.0001050117,0.00005247197,0.00009781883,0.004712229,0.00002115696,0.0000205482,0.001734347],"study_design_scores_gemma":[0.000007567189,0.0004201439,0.9970024,0.000004766794,0.00001806575,0.0011134,0.0001036976,0.000429307,0.0007211269,0.00005038405,0.000123851,0.000005347366],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992539,0.0003478963,0.0001386327,0.00001238819,0.000001635735,0.000002512754,0.00004879238,0.00000299354,0.0001911427],"genre_scores_gemma":[0.9997582,0.00005107048,0.00006634625,0.000006558333,0.000004033096,0.000002736513,0.00004874235,0.000001835611,0.00006039864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526998,"threshold_uncertainty_score":0.005108356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03949944288026137,"score_gpt":0.3163421000836,"score_spread":0.2768426572033386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}