{"id":"W2099298556","doi":"10.1136/bmjopen-2014-005376","title":"The cost-effectiveness and public health benefit of nalmefene added to psychosocial support for the reduction of alcohol consumption in alcohol-dependent patients with high/very high drinking risk levels: a Markov model","year":2014,"lang":"en","type":"article","venue":"BMJ Open","topic":"Substance Abuse Treatment and Outcomes","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Centre for Addiction and Mental Health","funders":"H. Lundbeck A/S; RTI International","keywords":"Nalmefene; Medicine; Psychosocial; Environmental health; Biostatistics; Public health; Population; Epidemiology; Alcohol consumption; Alcohol; Demography; Psychiatry; Naltrexone; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001850235,0.0001510762,0.0004397248,0.00008818109,0.0001815228,0.00003648085,0.0001770597,0.00005586619,0.00001259786],"category_scores_gemma":[0.0001370571,0.00008630321,0.00004880462,0.000149131,0.00007204423,0.0001777331,0.00006027626,0.0000889966,0.000001004429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001397598,"about_ca_system_score_gemma":0.0001436649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006495395,"about_ca_topic_score_gemma":0.002357875,"domain_scores_codex":[0.9985836,0.0001558208,0.0003935525,0.0002663719,0.0003476228,0.0002530237],"domain_scores_gemma":[0.9985676,0.0004239007,0.0004030388,0.0003293567,0.0001963932,0.00007965512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005362079,0.0002234397,0.903663,0.00007797334,0.0002448108,3.347503e-7,0.00111978,0.0002752955,0.00006083301,0.0004817294,0.00008798317,0.08840273],"study_design_scores_gemma":[0.01304809,0.0006526859,0.9840746,0.0002933725,0.0001069344,0.000002583631,0.0003561188,0.0004213275,0.000522717,0.0003978302,0.00002169544,0.0001020193],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985175,0.00003614274,0.0008660273,0.000915445,0.0001460341,0.0127604,0.0000512798,0.00000916651,0.00004056882],"genre_scores_gemma":[0.9970048,0.00007748012,0.001135315,0.0001176706,0.00003977226,0.001475035,0.00005891606,0.00001960116,0.00007140919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0883007,"threshold_uncertainty_score":0.3519343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176942274565284,"score_gpt":0.3937221681031352,"score_spread":0.2760279406466068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}