{"id":"W2099333268","doi":"10.1158/1541-7786.mcr-11-0185","title":"Suppression of IRF4 by IRF1, 3, and 7 in Noxa Expression Is a Necessary Event for IFN-γ–Mediated Tumor Elimination","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Chromatin immunoprecipitation; Biology; IRF1; Cancer research; Downregulation and upregulation; Cancer cell; Cell biology; Transcription factor; Cancer; Gene expression; Promoter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321419,0.0003928789,0.0002532124,0.0001775168,0.0001948967,0.0002048685,0.0001552835,0.0002648707,0.001395108],"category_scores_gemma":[0.0001014764,0.0001361191,0.0005314696,0.00008148373,0.0002325158,0.0002227226,0.0002063878,0.0007597567,0.0004375677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411757,"about_ca_system_score_gemma":0.0002069204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000205295,"about_ca_topic_score_gemma":0.0002033108,"domain_scores_codex":[0.9997924,0.00003284105,0.00001885371,0.00003958184,0.00003847751,0.00007792555],"domain_scores_gemma":[0.9998668,0.00001627298,0.00004511555,0.00002306728,0.0000197153,0.00002899816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008859542,0.00001607212,0.0002433988,0.00001545766,0.000002916154,0.00002845388,0.000007393489,0.0000204895,0.9990394,0.00007345014,0.00001404166,0.0004503503],"study_design_scores_gemma":[0.000009999811,0.0001115128,0.005798411,0.00000480254,0.0000122913,0.0001475283,0.00002519473,0.0004500576,0.9922113,0.00007945459,0.001146412,0.000002889564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924464,0.001402397,0.004526754,0.000109228,0.00004939466,0.00002451492,0.0003069889,0.00007778055,0.001056498],"genre_scores_gemma":[0.9961151,0.0003961631,0.001511155,0.00004723338,0.0000121395,0.00002562175,0.0005470354,0.00001619557,0.001329314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395108,"threshold_uncertainty_score":0.004667103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08046087860638543,"score_gpt":0.4049437029940104,"score_spread":0.324482824387625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}