{"id":"W2099335261","doi":"10.1073/pnas.1505870112","title":"Transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hospital for Sick Children; Jewish General Hospital; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; Sight Research UK; Macula Vision Research Foundation; Wellcome; Foundation Fighting Blindness","keywords":"Biology; Amacrine cell; Retina; Genetics; Retinal; Cell biology; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006898033,0.0002712244,0.0002063943,0.0002403711,0.0001701496,0.0002750205,0.0002646246,0.0002108877,0.001403668],"category_scores_gemma":[0.0001844109,0.0001796783,0.0001849629,0.0001274724,0.0001385183,0.0001774287,0.0002411372,0.000369954,0.0006296763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091081,"about_ca_system_score_gemma":0.0001775058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007060466,"about_ca_topic_score_gemma":0.00083079,"domain_scores_codex":[0.9998605,0.0000123123,0.0000186334,0.00003781836,0.00004266237,0.00002800141],"domain_scores_gemma":[0.9997839,0.00002051504,0.00008639247,0.00001881773,0.0000215885,0.0000688119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008554324,0.000008938299,0.001282353,0.00002430766,0.000003236707,0.0002234294,0.00001408901,0.00003123804,0.9966971,0.00007190793,0.00003464691,0.001523344],"study_design_scores_gemma":[0.000047286,0.0001878958,0.1072784,0.00002162942,0.00004277589,0.003411992,0.0001076239,0.001796335,0.8799272,0.0001827051,0.006983196,0.0000129001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956168,0.0008956346,0.001789748,0.00003801606,0.00001605924,0.000007314915,0.0004823419,0.00009871453,0.001055411],"genre_scores_gemma":[0.9955114,0.000378072,0.001174328,0.00001930792,0.00000634701,0.00001162539,0.0007823946,0.00003654058,0.002080063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403668,"threshold_uncertainty_score":0.004695714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04886063635997778,"score_gpt":0.3009388322862346,"score_spread":0.2520781959262568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}