{"id":"W2099373794","doi":"10.1371/journal.pgen.1001307","title":"Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Birth, Development, and Health","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Medical Research Council; Diabetes UK; Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; Erasmus Universiteit Rotterdam; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; ZonMw; Raine Medical Research Foundation; British Lung Foundation; Erasmus Medisch Centrum; University of Bristol; Biocenter, University of Oulu; Oulun Yliopisto; European Commission; Vetenskapsrådet; National Health and Medical Research Council; Academy of Finland; Women and Infants Research Foundation; National Institute for Health and Care Research; British Heart Foundation","keywords":"Body mass index; Allele; Minor allele frequency; Locus (genetics); Genotype; FTO gene; Demography; Biology; Obesity; Internal medicine; Genetics; Endocrinology; Allele frequency; Medicine; Polymorphism (computer science)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004326966,0.0008317227,0.00173725,0.001027272,0.0004642068,0.001474114,0.0007649161,0.0009268713,0.001364097],"category_scores_gemma":[0.005840113,0.0003928377,0.003684387,0.002012596,0.0005864956,0.0006105094,0.0006852605,0.0007261263,0.0001143016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005166324,"about_ca_system_score_gemma":0.0004248763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01005893,"about_ca_topic_score_gemma":0.01489373,"domain_scores_codex":[0.9980508,0.000611782,0.0002095759,0.0007846122,0.0001885249,0.0001546572],"domain_scores_gemma":[0.9967804,0.001878164,0.0006207991,0.0004666816,0.0001420211,0.0001120319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00333476,0.00003209928,0.9220983,0.001048761,0.0468314,0.0004671489,0.0002368263,0.001043207,0.003939065,0.0003757834,0.0004083414,0.02018425],"study_design_scores_gemma":[0.0001050639,0.0003453797,0.9684211,0.0002711547,0.02598918,0.0004306842,0.0001102552,0.001469808,0.000732156,0.0007853278,0.001316954,0.0000228994],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330115,0.05933768,0.004375253,0.0006187952,0.0001296423,0.00002431919,0.001693979,0.00009405927,0.0007145944],"genre_scores_gemma":[0.9936419,0.003622,0.00151331,0.0001401722,0.00005873611,0.00002402733,0.0006495066,0.00002926588,0.0003210774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01005893,"threshold_uncertainty_score":0.02288347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091666061103012,"score_gpt":0.2619675424032945,"score_spread":0.2310508817922643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}