{"id":"W2099373794","doi":"10.1371/journal.pgen.1001307","title":"Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Birth, Development, and Health","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Medical Research Council; Diabetes UK; Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; Erasmus Universiteit Rotterdam; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; ZonMw; Raine Medical Research Foundation; British Lung Foundation; Erasmus Medisch Centrum; University of Bristol; Biocenter, University of Oulu; Oulun Yliopisto; European Commission; Vetenskapsrådet; National Health and Medical Research Council; Academy of Finland; Women and Infants Research Foundation; National Institute for Health and Care Research; British Heart Foundation","keywords":"Body mass index; Allele; Minor allele frequency; Locus (genetics); Genotype; FTO gene; Demography; Biology; Obesity; Internal medicine; Genetics; Endocrinology; Allele frequency; Medicine; Polymorphism (computer science)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003554642,0.0001534479,0.0003030953,0.000063702,0.0001467789,0.00001579309,0.00009585896,0.000280462,0.00002433201],"category_scores_gemma":[0.0001047704,0.000108976,0.00001454023,0.0001792846,0.00002184529,0.00002826624,0.000107484,0.0003097171,0.000004638462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247236,"about_ca_system_score_gemma":0.0001023099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001991706,"about_ca_topic_score_gemma":0.001899811,"domain_scores_codex":[0.9985833,0.0001375534,0.0003746492,0.0002250061,0.0004285287,0.000251029],"domain_scores_gemma":[0.9990987,0.0001913665,0.000352632,0.0001694818,0.0001171933,0.00007062609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002534257,0.0000559401,0.9797634,0.00005147077,0.0001986094,6.115955e-7,0.01714836,0.000001177437,0.001683515,0.00006756013,0.00009594006,0.0009080527],"study_design_scores_gemma":[0.0007896037,0.00008969936,0.983305,0.00006812109,0.0001232279,4.80693e-7,0.0001329894,0.00006960288,0.01181344,0.003291809,0.0001972414,0.0001187418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947499,0.0007977266,0.00007348302,0.003091335,0.00006553298,0.0007742309,0.00004041371,0.00001556174,0.0003918386],"genre_scores_gemma":[0.988924,0.006456655,0.003057695,0.001301225,0.0001145571,0.00003083094,0.00007542741,0.00001998411,0.00001958134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01701537,"threshold_uncertainty_score":0.4443911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091666061103012,"score_gpt":0.2619675424032945,"score_spread":0.2310508817922643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}