{"id":"W2099378293","doi":"10.1039/b502123e","title":"A modular design of ruthenium catalysts with diamine and BINOL-derived phosphinite ligands that are enantiomerically-matched for the effective asymmetric transfer hydrogenation of simple ketones","year":2005,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Transfer hydrogenation; Phosphinite; Ruthenium; Diamine; Yield (engineering); Chemistry; Ligand (biochemistry); Catalysis; Combinatorial chemistry; Noyori asymmetric hydrogenation; Asymmetric hydrogenation; Modular design; Organic chemistry; Enantioselective synthesis; Materials science; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348714,0.0005524081,0.0003265724,0.0002020052,0.0001132261,0.0003554596,0.0007002635,0.0002627897,0.0006100516],"category_scores_gemma":[0.0001651783,0.0002671225,0.0002136835,0.000169627,0.0002538951,0.0004522137,0.0004059047,0.0005712329,0.0003947135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003392723,"about_ca_system_score_gemma":0.0002322398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002604302,"about_ca_topic_score_gemma":0.000467396,"domain_scores_codex":[0.9998988,0.000008518076,0.000009844233,0.00002696974,0.00002530378,0.00003053336],"domain_scores_gemma":[0.9999067,0.000008214356,0.00003659035,0.00001625153,0.000009732034,0.000022474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000120451,0.00004859689,0.0001673796,0.00008854867,0.00001361383,0.0001327822,0.00003281507,0.0008258863,0.9870089,0.001339649,0.0001220147,0.01009937],"study_design_scores_gemma":[0.00004314038,0.0002291801,0.0004083822,0.000004273439,0.00001766608,0.0002658819,0.000009089472,0.001621583,0.9937947,0.0001308162,0.003461655,0.00001369945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513198,0.001030774,0.0409926,0.0001585827,0.00005315401,0.0001792065,0.0002753498,0.0006913559,0.005299238],"genre_scores_gemma":[0.9754658,0.0006453078,0.02136612,0.00004775287,0.00001125586,0.00008215779,0.0003216375,0.00006286917,0.001997073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007002635,"threshold_uncertainty_score":0.002461612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02297493960233747,"score_gpt":0.2484131858617189,"score_spread":0.2254382462593815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}