{"id":"W2099390922","doi":"10.1073/pnas.0902971106","title":"Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":816,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Michael Smith Health Research BC; National Institute of Child Health and Human Development; Canadian Institute for Advanced Research; Heart and Stroke Foundation of Canada","keywords":"Proinflammatory cytokine; Allostatic load; Glucocorticoid receptor; Glucocorticoid; Biology; Phenotype; Immunology; Gene; Genetics; Inflammation; Physiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003376207,0.0001314049,0.0002014319,0.0001223481,0.0003353536,0.00006399995,0.0006091822,0.0001163573,0.00001058044],"category_scores_gemma":[0.002279324,0.00008803231,0.00007377732,0.0005529703,0.0009460881,0.0003286264,0.00009456384,0.0001814346,0.00000128615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000213702,"about_ca_system_score_gemma":0.00007086406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000665161,"about_ca_topic_score_gemma":2.972683e-8,"domain_scores_codex":[0.9979551,0.0000346063,0.000385159,0.0003875883,0.001006475,0.0002310296],"domain_scores_gemma":[0.9990091,0.0003306889,0.0004665931,0.000009092905,0.0001061719,0.00007830567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715817,0.00005790528,0.008120616,0.00002162907,0.000002969706,6.023731e-8,0.00008229929,0.000003452479,0.9802443,0.01059111,0.000132522,0.0005715751],"study_design_scores_gemma":[0.000259909,0.0001217481,0.3002945,0.00004724582,0.000005400201,0.000008677973,0.00008140303,0.0003199634,0.6933862,0.005370772,0.00001751132,0.00008662961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968565,0.00008621433,5.812531e-7,0.001850948,0.000007080359,0.0002884696,0.00001808813,0.00002503425,0.000867051],"genre_scores_gemma":[0.998703,0.00005083696,0.00009003626,0.001045007,0.00005397152,0.000009881404,8.405981e-8,0.000003850399,0.00004334795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.292174,"threshold_uncertainty_score":0.3589853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04762900295228422,"score_gpt":0.295681694659878,"score_spread":0.2480526917075938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}