{"id":"W2099410111","doi":"10.1038/sj.emboj.7601126","title":"Bcl‐2 changes conformation to inhibit Bax oligomerization","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mitochondrion; Cell biology; Mitochondrial apoptosis-induced channel; Cytochrome c; Mutant; Apoptosis; Inner mitochondrial membrane; Conformational change; Bcl-2-associated X protein; Transfection; Programmed cell death; Bacterial outer membrane; Biochemistry; Biophysics; Gene; Escherichia coli; Caspase 3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002030604,0.00006661811,0.00005088165,0.00003818306,0.0001724959,0.0000398323,0.00008087898,0.00004486725,0.00004116682],"category_scores_gemma":[0.00001018463,0.00004459807,0.00003294147,0.00006537957,0.00001304836,0.000004625247,0.00002892683,0.00005288547,0.00002020917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001053916,"about_ca_system_score_gemma":0.00001733203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009178996,"about_ca_topic_score_gemma":0.00002919895,"domain_scores_codex":[0.9995441,0.00002838707,0.0001272705,0.00006789582,0.0001126277,0.0001196577],"domain_scores_gemma":[0.9997072,0.000002613071,0.00008156311,0.0001023631,0.00006864349,0.00003766825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002575036,0.00001200965,0.0000421664,0.000003039617,0.000008551161,7.828904e-7,0.00008024787,0.001687438,0.9793119,0.0009256945,0.005204013,0.01269834],"study_design_scores_gemma":[0.0006178786,0.0003244684,0.005743966,0.00002213546,0.00002845108,0.0003534985,0.0001824808,0.0009671494,0.6839629,0.00263421,0.3049279,0.0002349555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516801,0.0003873368,0.04230931,0.002101862,0.000332921,0.0001546881,0.000003366159,0.000009059575,0.003021338],"genre_scores_gemma":[0.9959285,0.000199014,0.000390264,0.0004257669,0.001113292,0.000004199811,0.00007388712,0.000009559768,0.001855564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2997238,"threshold_uncertainty_score":0.1818657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005383861999865899,"score_gpt":0.213023628171892,"score_spread":0.2076397661720261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}