{"id":"W2099429097","doi":"10.1371/journal.pone.0099211","title":"Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO; Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Fludarabine; Indoleamine 2,3-dioxygenase; Cancer research; STAT protein; STAT1; Proteasome inhibitor; Proteasome; Biology; Medicine; Immunology; Signal transduction; Interferon; Cell biology; Internal medicine; STAT3; Biochemistry; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824391,0.000207484,0.0002992234,0.0002646197,0.00009445946,0.00004186485,0.0002664371,0.00009190965,0.0001602202],"category_scores_gemma":[0.001815102,0.0001951348,0.00004128844,0.0006454737,0.00007699229,0.0002294947,0.00006406356,0.0002560049,0.0003760557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004584398,"about_ca_system_score_gemma":0.0000290685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000328484,"about_ca_topic_score_gemma":0.00005424767,"domain_scores_codex":[0.9981106,0.0002452181,0.0003144273,0.0004809384,0.0004562671,0.0003925792],"domain_scores_gemma":[0.9991737,0.0002324116,0.0001187109,0.000315421,0.0000369372,0.0001228412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005853584,0.001431987,0.0001471813,0.00006235499,0.000006331049,0.000008899989,0.000109408,0.000006637722,0.9960112,0.001222944,0.00001515488,0.0009193671],"study_design_scores_gemma":[0.001671834,0.0001851261,0.005290132,0.0001206577,0.000004496595,0.00000320515,0.00002566676,0.009293377,0.9788886,0.004252739,0.00002137631,0.0002428082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975617,0.00001879502,0.0004041407,0.0005653408,0.0000278855,0.0007972669,0.0000118691,0.0002086803,0.0004043042],"genre_scores_gemma":[0.9979515,0.00001300386,0.0007591824,0.0005980671,0.00005805057,0.000137754,0.00002941021,0.00003436169,0.0004186545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01712262,"threshold_uncertainty_score":0.7957367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02887847675133313,"score_gpt":0.2094518726631019,"score_spread":0.1805733959117687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}