{"id":"W2099447852","doi":"10.1038/sj.bjp.0707391","title":"Imbalanced synthesis of cyclooxygenase‐derived thromboxane A<sub>2</sub> and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome","year":2007,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Phenylephrine; Thromboxane; Internal medicine; Prostacyclin; Medicine; Marfan syndrome; Endocrinology; Thromboxane A2; Cyclooxygenase; Aorta; Vasomotor; Thoracic aorta; Cardiology; Anesthesia; Chemistry; Blood pressure; Platelet; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008626296,0.0001187136,0.0003720331,0.0001144135,0.00005075587,0.000008680202,0.0002391376,0.0001296904,0.00003058064],"category_scores_gemma":[0.0002978237,0.0001170976,0.0001164649,0.0001862011,0.0002964737,0.00001193925,0.0001286899,0.0002523977,3.986001e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525125,"about_ca_system_score_gemma":0.0001197985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000471002,"about_ca_topic_score_gemma":0.0002370692,"domain_scores_codex":[0.9984975,0.0002924831,0.000550256,0.0001981758,0.0001995443,0.0002620345],"domain_scores_gemma":[0.9990014,0.0001380373,0.0004197612,0.00009539304,0.000276811,0.00006863601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008207003,0.0002361745,0.0095519,0.0001076722,0.0001752118,0.0001264124,0.00002842577,0.0000170805,0.96087,0.00000146255,0.000138899,0.02792602],"study_design_scores_gemma":[0.0009836874,0.0003468484,0.3163361,0.00008911818,0.00005303299,0.0007239208,0.00009639309,0.000008448419,0.6812082,0.00003090308,0.0000498755,0.00007349787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995703,0.003414548,0.0001382667,0.0001035126,0.0001953678,0.0003727517,0.00003112564,0.00000204858,0.00003937753],"genre_scores_gemma":[0.9980572,0.001707932,0.00008771323,0.00004534398,0.00006042405,0.00001001893,0.00000369696,0.00001807209,0.000009562673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3067842,"threshold_uncertainty_score":0.4775102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00959363374978721,"score_gpt":0.2943884323355637,"score_spread":0.2847947985857765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}