{"id":"W2099472440","doi":"10.3390/cancers7040877","title":"Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1","year":2015,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Cancer Society; Saskatchewan Health Research Foundation","keywords":"ATP-binding cassette transporter; Drug resistance; Drug; Transporter; Pharmacology; Medicine; Computational biology; Intensive care medicine; Biology; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003287162,0.0001949719,0.0005135763,0.00003026943,0.00005628374,0.000006631793,0.0001280042,0.0001643432,0.000004521607],"category_scores_gemma":[0.00003053632,0.0001396929,0.00009064555,0.00007403034,0.0003046159,0.000002037471,0.00006192901,0.00007784446,2.766452e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227143,"about_ca_system_score_gemma":0.000645604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003267012,"about_ca_topic_score_gemma":0.0007233887,"domain_scores_codex":[0.9989864,0.00004727569,0.0003939068,0.0003003756,0.0001209441,0.000151142],"domain_scores_gemma":[0.9992049,0.000022652,0.0003505763,0.0002641075,0.00009344851,0.00006430971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003813047,0.00002643891,0.001553162,0.02250752,0.0008202495,0.000006225684,0.00184486,0.0000293065,0.008153203,0.00005745681,0.02135331,0.943267],"study_design_scores_gemma":[0.0003127922,0.00001932176,0.00007954105,0.0008809289,0.0001173113,0.000001111556,0.00004647847,9.968826e-7,0.002748369,0.00001047468,0.9956254,0.0001573235],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01461256,0.9843346,0.00005670665,0.000009956384,0.0001044554,0.0002980269,0.0001306743,0.000002002493,0.0004509829],"genre_scores_gemma":[0.002372544,0.9936237,0.000646383,0.00001121408,0.00004526306,0.00002500174,0.0001966096,0.00002397705,0.003055339],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9742721,"threshold_uncertainty_score":0.5696509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562881488106451,"score_gpt":0.2947398686116707,"score_spread":0.2691110537306062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}