{"id":"W2099472440","doi":"10.3390/cancers7040877","title":"Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1","year":2015,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Cancer Society; Saskatchewan Health Research Foundation","keywords":"ATP-binding cassette transporter; Drug resistance; Drug; Transporter; Pharmacology; Medicine; Computational biology; Intensive care medicine; Biology; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002838003,0.000524984,0.0008263749,0.001636555,0.0002513653,0.0006365997,0.0005276758,0.0007595406,0.002772295],"category_scores_gemma":[0.000423932,0.0001984168,0.000316768,0.001227559,0.00039761,0.0009773877,0.0004764898,0.001286333,0.001552785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000530235,"about_ca_system_score_gemma":0.0007491933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008214078,"about_ca_topic_score_gemma":0.00165909,"domain_scores_codex":[0.9998944,0.00001620343,0.00001537696,0.00002041663,0.00004013858,0.00001338639],"domain_scores_gemma":[0.999854,0.00005697028,0.00002434871,0.000005000399,0.00004038441,0.00001935305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005592443,0.00005669352,0.0002793482,0.01257073,0.00005923659,0.0003069901,0.000079915,0.0003119768,0.0040459,0.005159806,0.02716632,0.9499071],"study_design_scores_gemma":[0.000008267977,0.00007012876,0.0008031923,0.001303309,0.00005202916,0.00196705,0.00004988953,0.00007685966,0.001113721,0.001861498,0.9926803,0.00001371643],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000178895,0.9980738,0.0001848429,0.0002710164,0.000144295,0.000003781552,0.00001681285,0.000009501364,0.001116951],"genre_scores_gemma":[0.001212163,0.9974705,0.0002152595,0.0001678202,0.0001132399,0.000005551814,0.00003258545,0.000002029678,0.0007808739],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002772295,"threshold_uncertainty_score":0.009274244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562881488106451,"score_gpt":0.2947398686116707,"score_spread":0.2691110537306062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}