{"id":"W2099474750","doi":"10.1124/dmd.113.052613","title":"The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation","year":2013,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Glucuronidation; Enzyme; Glucuronosyltransferase; Biochemistry; Chemistry; Isozyme; Bile acid; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003734642,0.0005286671,0.0006675985,0.0006199063,0.0002233124,0.0008744781,0.0001106261,0.0004036281,0.001435685],"category_scores_gemma":[0.000944458,0.0002493074,0.0004854413,0.001162532,0.0002534167,0.0002364817,0.0002525705,0.0003815701,0.0006610571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004143384,"about_ca_system_score_gemma":0.0003211097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002249645,"about_ca_topic_score_gemma":0.001750966,"domain_scores_codex":[0.9995414,0.0001853258,0.00002025938,0.0000899512,0.000114671,0.00004845382],"domain_scores_gemma":[0.9996911,0.00006854191,0.0001055603,0.00003087343,0.00006785439,0.00003604586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003805457,0.000318454,0.215171,0.0006696047,0.00200049,0.002171715,0.0003667296,0.003033334,0.4590138,0.004829798,0.008276897,0.3003426],"study_design_scores_gemma":[0.0002087825,0.001290454,0.4553406,0.00005556901,0.0006843428,0.01120421,0.0001853449,0.005079324,0.4092034,0.002386783,0.1142804,0.00008085011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9152754,0.03754142,0.02775815,0.001004278,0.0002141074,0.0001126637,0.004554826,0.000756692,0.01278253],"genre_scores_gemma":[0.9783812,0.004692039,0.005985716,0.0002151659,0.0000785285,0.00003710839,0.003146919,0.00009330863,0.007370105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002249645,"threshold_uncertainty_score":0.004802883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751561971026592,"score_gpt":0.3443380838293738,"score_spread":0.3168224641191079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}