{"id":"W2099475198","doi":"10.1210/me.2010-0034","title":"Hydrogen Peroxide Mediates EGF-Induced Down-Regulation of E-Cadherin Expression via p38 MAPK and Snail in Human Ovarian Cancer Cells","year":2010,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cadherin; Snail; Hydrogen peroxide; Cancer research; MAPK/ERK pathway; Cell biology; p38 mitogen-activated protein kinases; Epidermal growth factor; Signal transduction; Cell culture; Cell; Biochemistry; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008817486,0.000238792,0.0001862405,0.0001217615,0.0001108459,0.0001215013,0.00008145211,0.0001112053,0.001038875],"category_scores_gemma":[0.00006796227,0.0001224711,0.0002405046,0.0000997401,0.0001110001,0.0001323644,0.0001489055,0.000267802,0.0001835053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217714,"about_ca_system_score_gemma":0.000124994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000553755,"about_ca_topic_score_gemma":0.0007003082,"domain_scores_codex":[0.9999398,0.00001187677,0.00000545536,0.0000076479,0.00001547767,0.00001965366],"domain_scores_gemma":[0.9999709,0.000005048948,0.000008525395,0.000002965676,0.000005464929,0.000007050729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001574599,0.00004025993,0.0002322292,0.00005508835,0.000004275742,0.00007983221,0.00002521931,0.00001964408,0.9983531,0.00003206024,0.00003359468,0.0009673153],"study_design_scores_gemma":[0.00004348014,0.0005290884,0.01433818,0.000004577981,0.00001609038,0.0002937036,0.00005652516,0.0006940594,0.982479,0.00004601695,0.001495783,0.000003661271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996115,0.001935029,0.0008564649,0.00006528009,0.00001617914,0.00003182542,0.0001273466,0.00002990796,0.0008230414],"genre_scores_gemma":[0.9967673,0.001058705,0.0004485294,0.00002861347,0.00000617316,0.00003578099,0.0002289714,0.000003077508,0.001422785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038875,"threshold_uncertainty_score":0.003475368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00730943123646059,"score_gpt":0.248383775522604,"score_spread":0.2410743442861434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}