{"id":"W2099504516","doi":"10.6064/2012/238278","title":"The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance","year":2012,"lang":"en","type":"review","venue":"Scientifica","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Integrase; Nucleoside Reverse Transcriptase Inhibitor; Virology; Drug resistance; Reverse-transcriptase inhibitor; Integrase inhibitor; Drug; Human immunodeficiency virus (HIV); Biology; Antiretroviral therapy; Medicine; Pharmacology; Viral load; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005969719,0.0007212865,0.001249345,0.002176712,0.000259315,0.000884268,0.0006605089,0.001226193,0.004321031],"category_scores_gemma":[0.0005868727,0.0002473645,0.0004977567,0.001787288,0.0004305474,0.001941201,0.0005482939,0.00208624,0.002487436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005077689,"about_ca_system_score_gemma":0.001187658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007376318,"about_ca_topic_score_gemma":0.001284271,"domain_scores_codex":[0.9997792,0.00004124112,0.00002742445,0.00003277191,0.00009726548,0.00002219049],"domain_scores_gemma":[0.9996585,0.000121321,0.00005712157,0.00001352965,0.0001197366,0.00002979626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006367173,0.0001157385,0.0001320614,0.01649326,0.00006602105,0.0002658507,0.00007135725,0.0003201652,0.004517694,0.004096659,0.02322776,0.9506298],"study_design_scores_gemma":[0.00002013081,0.0001006362,0.0006303798,0.003036469,0.00008503693,0.001447382,0.0000746555,0.00007717665,0.0008308608,0.001843657,0.9918398,0.00001379259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001701103,0.9980009,0.0001553682,0.0003876755,0.0001976462,0.000005372871,0.00001032477,0.000008443449,0.001064053],"genre_scores_gemma":[0.0006910182,0.9978137,0.0002959495,0.0002789809,0.0001749511,0.000005523032,0.00002492776,0.000001309919,0.000713662],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004321031,"threshold_uncertainty_score":0.01445532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05507156477732356,"score_gpt":0.3180143730300801,"score_spread":0.2629428082527566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}