{"id":"W2099505694","doi":"10.1158/2159-8290.cd-11-0224","title":"Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells","year":2011,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; St. Michael's Hospital; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Small hairpin RNA; Biology; Breast cancer; Ovarian cancer; Pancreatic cancer; Cancer; Gene; Functional genomics; Computational biology; Genomics; Genome; Synthetic lethality; Bioinformatics; Cancer research; Genetics; Mutant; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008312,0.0002005034,0.0002286365,0.0004202005,0.0002699369,0.0003690182,0.0001751063,0.0001664335,0.001309722],"category_scores_gemma":[0.0001737571,0.00008138278,0.0001890462,0.0006465277,0.0001073711,0.0001479645,0.0002905176,0.0002947294,0.0006916944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003778374,"about_ca_system_score_gemma":0.0004046324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002291046,"about_ca_topic_score_gemma":0.003988618,"domain_scores_codex":[0.9998565,0.000009095198,0.0000167468,0.0000336228,0.00005225776,0.00003177001],"domain_scores_gemma":[0.9998724,0.00002005302,0.00002213064,0.00001955045,0.0000347745,0.00003090001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001528415,0.00002497708,0.003481122,0.00005620438,0.00001057993,0.0001008321,0.00003362565,0.0001418638,0.9897261,0.0000761796,0.0002255896,0.005970004],"study_design_scores_gemma":[0.00002401608,0.0002881367,0.06520705,0.00001245852,0.00005742502,0.0009744402,0.0001635436,0.001414073,0.9208413,0.000130411,0.01087459,0.00001263806],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807108,0.001999224,0.005810828,0.0001367461,0.00002004659,0.00007321482,0.007888671,0.0002591395,0.003101335],"genre_scores_gemma":[0.9672967,0.001563599,0.01037498,0.000139854,0.000005518492,0.0001304423,0.016544,0.00007034809,0.003874511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002291046,"threshold_uncertainty_score":0.004555404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008949994002293536,"score_gpt":0.2285446214838701,"score_spread":0.2195946274815765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}