{"id":"W2099539451","doi":"10.1038/clpt.2012.179","title":"Epigenetics: A New Link Toward Understanding Human Disease and Drug Response","year":2012,"lang":"en","type":"editorial","venue":"Clinical Pharmacology & Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Epigenomics; Epigenetics; Clinical pharmacology; Human disease; Computational biology; Drug response; Human health; Genomics; Phenotype; Biology; Drug; Pharmacology; Genetics; Gene; Medicine; Genome; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004881446,0.002829084,0.002171222,0.001775993,0.001443008,0.004441448,0.002336014,0.009872753,0.004778881],"category_scores_gemma":[0.011226,0.0007496233,0.001520635,0.0008199352,0.003672118,0.005215619,0.001703348,0.0248581,0.003013389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001935245,"about_ca_system_score_gemma":0.001661947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009499562,"about_ca_topic_score_gemma":0.00234488,"domain_scores_codex":[0.9978153,0.0005749604,0.0002805415,0.0003045546,0.0009376873,0.00008694826],"domain_scores_gemma":[0.9903019,0.005952011,0.0003983965,0.0002697169,0.002260595,0.0008173321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005508537,0.00001472095,0.00004937878,0.0004212181,0.00003555657,0.000166256,0.00004340615,0.00006246099,0.0002368073,0.002061044,0.9704718,0.0263823],"study_design_scores_gemma":[0.00003129754,0.00002940292,0.0002045258,0.0003222568,0.00004323545,0.0004934184,0.00004825246,0.000146835,0.0001548079,0.004644974,0.9938623,0.00001878192],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00008035622,0.05977561,0.0008066473,0.1085575,0.8290892,0.00001410338,0.00004357536,0.0000693912,0.001563772],"genre_scores_gemma":[0.0007630446,0.03639915,0.0004073164,0.02754977,0.9286984,0.00001446812,0.00001766367,0.00002151525,0.006128614],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.009872753,"threshold_uncertainty_score":0.02581584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1210040032366081,"score_gpt":0.4349502218091449,"score_spread":0.3139462185725368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}