{"id":"W2099546758","doi":"10.1152/ajpheart.00919.2007","title":"p38 and ERK1/2 MAPKs mediate the interplay of TNF-α and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Cardiac myocyte; Oxidative stress; Apoptosis; p38 mitogen-activated protein kinases; Myocyte; Cell biology; Tumor necrosis factor alpha; Chemistry; Internal medicine; Biology; Signal transduction; Medicine; MAPK/ERK pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006943053,0.0002164475,0.001113475,0.0001844576,0.00009311056,0.000007817959,0.00006178665,0.0001110338,0.000007335801],"category_scores_gemma":[0.00006870751,0.0001451851,0.0001442525,0.000166872,0.001477736,0.00009134835,0.0001101801,0.0004265697,3.095854e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002440404,"about_ca_system_score_gemma":0.00005224926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000690313,"about_ca_topic_score_gemma":0.000003783254,"domain_scores_codex":[0.9984279,0.0002268077,0.0005701415,0.0003284412,0.0001372765,0.0003094831],"domain_scores_gemma":[0.9985967,0.0004444777,0.0004585338,0.0001970686,0.0001381771,0.0001650724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000449934,0.0000396022,0.01862773,0.00008643171,0.0002170966,2.838296e-7,0.001207569,0.00002803445,0.9750077,0.00004533424,0.00002684188,0.004263473],"study_design_scores_gemma":[0.0008336667,0.0008171416,0.9812041,0.0002403973,0.000149037,0.00007183476,0.003401325,0.0001669546,0.01259796,0.0002513392,0.0001244215,0.0001418463],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996608,0.002871317,0.000002694728,0.0001915202,0.000136682,0.0001440881,0.00001216179,0.000005111611,0.00002846722],"genre_scores_gemma":[0.9983819,0.0008879938,0.0002363437,0.0002087799,0.0002548992,0.00000204962,0.000004499553,0.00001827569,0.00000528166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9625763,"threshold_uncertainty_score":0.5920475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008749325090452101,"score_gpt":0.2642681073656009,"score_spread":0.2555187822751488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}