{"id":"W2099546847","doi":"10.1186/s12958-015-0033-0","title":"Activity of the porcine gonadotropin-releasing hormone receptor gene promoter is partially conferred by a distal gonadotrope specific element (GSE) within an upstream enhancing region, two proximal GSEs and a retinoid X receptor binding site","year":2015,"lang":"en","type":"article","venue":"Reproductive Biology and Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Cooperative State Research, Education, and Extension Service; National Institute of Food and Agriculture; Colorado State University; U.S. Department of Agriculture","keywords":"GNRHR; Gonadotropic cell; Biology; Gonadotropin-releasing hormone receptor; Reporter gene; Steroidogenic factor 1; Endocrinology; Gonadotropin-releasing hormone; Internal medicine; Transcription factor; Receptor; Luteinizing hormone; Molecular biology; Gene; Cell biology; Nuclear receptor; Hormone; Gene expression; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005245117,0.000476956,0.0009783829,0.0001585379,0.0002437661,0.00002150278,0.0001714038,0.0001849565,0.00002022637],"category_scores_gemma":[0.0006350161,0.0003444612,0.0001021818,0.0002157725,0.001452579,0.000220743,0.0002975622,0.0005368504,0.00001047206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000180964,"about_ca_system_score_gemma":0.0002066958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002766199,"about_ca_topic_score_gemma":0.0000347278,"domain_scores_codex":[0.9960073,0.00066707,0.0006675732,0.001740606,0.0002111793,0.0007062221],"domain_scores_gemma":[0.9976111,0.00007289119,0.0005991051,0.00102229,0.0004609634,0.0002336207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00395115,0.0003532442,0.06837474,0.00003783442,0.000287583,0.00001641251,0.002094868,0.000001048869,0.9154389,0.0002179201,0.0005261922,0.008700132],"study_design_scores_gemma":[0.005572698,0.004094325,0.1105813,0.00008495153,0.0002474631,0.00148065,0.0006836217,0.00003475492,0.863805,0.0002307868,0.01264667,0.0005377977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836545,0.004843986,0.000387397,0.008946404,0.0004345942,0.001467622,0.0001219631,0.00007795219,0.00006561081],"genre_scores_gemma":[0.9958915,0.001024002,0.00164495,0.00008223649,0.000748009,0.00008137371,0.0001048899,0.00005026376,0.0003727718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05163385,"threshold_uncertainty_score":0.9999008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119369316958705,"score_gpt":0.2782277295592246,"score_spread":0.2470340363896375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}