{"id":"W2099546847","doi":"10.1186/s12958-015-0033-0","title":"Activity of the porcine gonadotropin-releasing hormone receptor gene promoter is partially conferred by a distal gonadotrope specific element (GSE) within an upstream enhancing region, two proximal GSEs and a retinoid X receptor binding site","year":2015,"lang":"en","type":"article","venue":"Reproductive Biology and Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Cooperative State Research, Education, and Extension Service; National Institute of Food and Agriculture; Colorado State University; U.S. Department of Agriculture","keywords":"GNRHR; Gonadotropic cell; Biology; Gonadotropin-releasing hormone receptor; Reporter gene; Steroidogenic factor 1; Endocrinology; Gonadotropin-releasing hormone; Internal medicine; Transcription factor; Receptor; Luteinizing hormone; Molecular biology; Gene; Cell biology; Nuclear receptor; Hormone; Gene expression; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236922,0.0004640911,0.0002532752,0.0002753818,0.0001207028,0.0002285487,0.0002179503,0.0002452539,0.002098812],"category_scores_gemma":[0.0002238543,0.0002656575,0.0005629263,0.0001446775,0.0005215977,0.0001361799,0.0003218741,0.0005980911,0.001225725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411893,"about_ca_system_score_gemma":0.0003207762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546217,"about_ca_topic_score_gemma":0.0004542085,"domain_scores_codex":[0.9997345,0.00003954257,0.00002323892,0.0000820417,0.00006802541,0.00005268531],"domain_scores_gemma":[0.9997507,0.00007796534,0.00007285336,0.00003217693,0.00001700162,0.00004932689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008356712,0.00002044433,0.0002377624,0.00003292059,0.000004203704,0.00005850791,0.00001335939,0.00003528278,0.9985436,0.00007853819,0.0000218064,0.000869973],"study_design_scores_gemma":[0.0001013247,0.0004452472,0.01273927,0.00003156668,0.00003405232,0.00135621,0.00004629702,0.001590975,0.9783366,0.0001310693,0.005170942,0.00001637273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862417,0.0008790602,0.0091224,0.0001600245,0.00005673628,0.00004591753,0.0007266696,0.00016922,0.002598144],"genre_scores_gemma":[0.9834486,0.0006597773,0.008032959,0.0001408551,0.00003239767,0.00006451556,0.004191634,0.00008633909,0.003342945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098812,"threshold_uncertainty_score":0.007021189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119369316958705,"score_gpt":0.2782277295592246,"score_spread":0.2470340363896375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}