{"id":"W2099562966","doi":"10.1016/s0140-6736(13)62674-4","title":"DNA methylation and body-mass index: a genome-wide analysis","year":2014,"lang":"en","type":"article","venue":"The Lancet","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":793,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Public Health Ontario","funders":"Helmholtz Zentrum München; Fondation pour la Recherche Médicale; Bundesministerium für Bildung und Forschung; European Commission; King's College London; Canadian Institutes of Health Research; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust; NIHR BioResource; Heart and Stroke Foundation of Canada","keywords":"DNA methylation; Methylation; Cohort; Body mass index; Epigenetics; CpG site; Genetics; Genome-wide association study; Genetic association; Biology; Oncology; Medicine; Internal medicine; Gene; Genotype; Single-nucleotide polymorphism; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008284541,0.0004790632,0.0005966844,0.0007079678,0.000283392,0.0004798181,0.0004934432,0.0005458944,0.001935974],"category_scores_gemma":[0.001142049,0.0003671612,0.001281591,0.001984103,0.0002218925,0.0002327241,0.0005078031,0.0006750973,0.0002216534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000268414,"about_ca_system_score_gemma":0.0003390276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00757447,"about_ca_topic_score_gemma":0.01257798,"domain_scores_codex":[0.9995614,0.0001407209,0.0000203688,0.0001589835,0.00006349981,0.00005499645],"domain_scores_gemma":[0.99953,0.0001720345,0.00008297931,0.00005975749,0.00005821132,0.00009705011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001623947,0.00002998284,0.9751413,0.00009159859,0.003721033,0.000273441,0.0001191491,0.0002354803,0.005304436,0.0001149647,0.001087142,0.01225751],"study_design_scores_gemma":[0.00002843936,0.00008508112,0.9974312,0.000006753221,0.0009488688,0.0002389502,0.00005023785,0.0002143624,0.0002011644,0.00007635537,0.000712114,0.000006418791],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867088,0.005857076,0.001401504,0.0007715843,0.00004621286,0.00001633893,0.004356761,0.00003560148,0.0008061556],"genre_scores_gemma":[0.9958279,0.001149928,0.0007913868,0.0001798833,0.00005664733,0.00001345099,0.001329047,0.00001236857,0.0006395255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00757447,"threshold_uncertainty_score":0.01506078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223471946487438,"score_gpt":0.2553138061754293,"score_spread":0.2430790867105549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}