{"id":"W2099576234","doi":"10.1128/jvi.78.10.5205-5215.2004","title":"The V1/V2 Domain of gp120 Is a Global Regulator of the Sensitivity of Primary Human Immunodeficiency Virus Type 1 Isolates to Neutralization by Antibodies Commonly Induced upon Infection","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Center for AIDS Research, University of Washington; U.S. Public Health Service; York University; U.S. Department of Veterans Affairs","keywords":"Neutralization; Virology; Biology; Antibody; Monoclonal antibody; Virus; Neutralizing antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479568,0.0003143822,0.0002354885,0.0001958903,0.0001379183,0.0003142761,0.0001641527,0.0002575294,0.0009136426],"category_scores_gemma":[0.0002246679,0.00012887,0.0001835184,0.00008610659,0.0001701211,0.0001199279,0.0001526098,0.0003613232,0.0002666677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434048,"about_ca_system_score_gemma":0.00007616375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005537386,"about_ca_topic_score_gemma":0.0005356539,"domain_scores_codex":[0.9998248,0.00003019475,0.00001355042,0.00003457912,0.00004489631,0.00005191808],"domain_scores_gemma":[0.9998713,0.00003445609,0.00002935637,0.00001571188,0.00001927841,0.00002987215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003605389,0.000008418237,0.0009800593,0.0000142661,0.000004432961,0.00002627847,0.000006361864,0.00005165704,0.9980259,0.00001255567,0.00001427184,0.0008197691],"study_design_scores_gemma":[0.00001849474,0.0005646507,0.09501385,0.00001062932,0.00003612558,0.001738122,0.00003963187,0.0008788058,0.8999221,0.00007557144,0.00169494,0.000006970042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969856,0.00123152,0.0006683258,0.00002854391,0.000005043586,0.00001272477,0.00006331353,0.00003412806,0.0009708426],"genre_scores_gemma":[0.9988335,0.0002801674,0.0002459271,0.00002899627,0.000007142503,0.000007485429,0.0001597087,0.000005418325,0.0004315818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009136426,"threshold_uncertainty_score":0.003056467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126384841161929,"score_gpt":0.2781461146429398,"score_spread":0.2655076305267469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}