{"id":"W2099576234","doi":"10.1128/jvi.78.10.5205-5215.2004","title":"The V1/V2 Domain of gp120 Is a Global Regulator of the Sensitivity of Primary Human Immunodeficiency Virus Type 1 Isolates to Neutralization by Antibodies Commonly Induced upon Infection","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Center for AIDS Research, University of Washington; U.S. Public Health Service; York University; U.S. Department of Veterans Affairs","keywords":"Neutralization; Virology; Biology; Antibody; Monoclonal antibody; Virus; Neutralizing antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006131246,0.0001067812,0.0003533447,0.00007028841,0.0001847232,0.000004558782,0.0001585422,0.0001644983,0.00001395219],"category_scores_gemma":[0.00009305587,0.00006258609,0.0001293301,0.0002269476,0.0002944916,0.0000599939,0.00008831819,0.0002106286,0.000006691494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052118,"about_ca_system_score_gemma":0.000150065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009227979,"about_ca_topic_score_gemma":0.0004336426,"domain_scores_codex":[0.9985818,0.0005577979,0.0004910427,0.0000937422,0.00007220777,0.000203436],"domain_scores_gemma":[0.9988478,0.0001060425,0.0005605922,0.0002130019,0.0002539517,0.00001859816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007598307,0.0003802627,0.02403262,0.00001383372,0.0002091669,0.000002143793,0.0004196625,0.00006763764,0.9723404,0.000624124,0.0003219335,0.0008283695],"study_design_scores_gemma":[0.00159497,0.00294344,0.4766842,0.00004713088,0.00006929279,0.0001943957,0.0000661123,9.975596e-7,0.5163125,0.00120172,0.0008212439,0.00006393858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99696,0.001521803,0.0001343476,0.0008165396,0.0002403565,0.0001667655,0.00006429961,0.000003296935,0.0000925565],"genre_scores_gemma":[0.9996336,0.0002350141,0.00002372126,0.00006616506,0.000009767942,9.514785e-7,0.000009506937,0.000005080354,0.00001617819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4560279,"threshold_uncertainty_score":0.2552187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126384841161929,"score_gpt":0.2781461146429398,"score_spread":0.2655076305267469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}