{"id":"W2099591397","doi":"10.1158/1535-7163.mct-08-0929","title":"Base excision repair of reactive oxygen species–initiated 7,8-dihydro-8-oxo-2′-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Environmental Health Sciences","keywords":"Oxaliplatin; Cisplatin; Reactive oxygen species; DNA damage; DNA glycosylase; DNA repair; Cytotoxicity; Chemistry; Base excision repair; Pharmacology; Cancer research; Biochemistry; Molecular biology; Biology; Cancer; DNA; Chemotherapy; In vitro; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791333,0.0003321758,0.0004190562,0.0001813885,0.00007027169,0.0001949415,0.0002000469,0.0002319904,0.0006939582],"category_scores_gemma":[0.0001564751,0.0001248501,0.0002230371,0.0001241042,0.000118115,0.0001589495,0.0001295421,0.0003501673,0.0002095573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001797165,"about_ca_system_score_gemma":0.000185874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000337913,"about_ca_topic_score_gemma":0.0004911553,"domain_scores_codex":[0.9998841,0.00002788474,0.00001213029,0.00002249922,0.00002205669,0.00003121915],"domain_scores_gemma":[0.9999244,0.00001212429,0.00002340375,0.00001230245,0.00001231441,0.00001554928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005943554,0.00004032559,0.0001108224,0.00003233594,0.000004356846,0.00001348565,0.000005618109,0.00008304425,0.9975001,0.00005287451,0.00002150155,0.002076053],"study_design_scores_gemma":[0.00002155757,0.0006965584,0.002428462,0.000006192388,0.000009956523,0.0001261857,0.000006215024,0.0008374663,0.9941254,0.00002960885,0.001710413,0.000002005354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887576,0.004886799,0.004859328,0.00008316648,0.00004136935,0.00003861501,0.00006700412,0.0001347731,0.001131443],"genre_scores_gemma":[0.9941419,0.001959872,0.002156365,0.00004115723,0.00001323972,0.00002526215,0.0001994588,0.000009832303,0.001452803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006939582,"threshold_uncertainty_score":0.002321482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397552763312264,"score_gpt":0.2807184961561233,"score_spread":0.2567429685230007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}