{"id":"W2099597763","doi":"10.1152/ajpheart.00260.2008","title":"Shared requirement for dynein function and intact microtubule cytoskeleton for normal surface expression of cardiac potassium channels","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Nocodazole; Cell biology; Myocyte; Potassium channel; Microtubule; Cardiac myocyte; Heterologous expression; Cardiac action potential; Dynein; Chemistry; Cytoskeleton; Inward-rectifier potassium ion channel; Biology; Internal medicine; Biophysics; Ion channel; Electrophysiology; Biochemistry; Neuroscience; Cell; Repolarization; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116795,0.0002060377,0.0002464297,0.0001292427,0.0001443839,0.0003239163,0.0001862922,0.0002053765,0.0005803024],"category_scores_gemma":[0.000196916,0.0001199373,0.0001826915,0.0000595228,0.0001885469,0.0002519831,0.0002945364,0.0003500044,0.0002185157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003616897,"about_ca_system_score_gemma":0.0002000379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005030655,"about_ca_topic_score_gemma":0.001194073,"domain_scores_codex":[0.9998184,0.00001717791,0.00002698658,0.00004709008,0.00004646191,0.00004399651],"domain_scores_gemma":[0.9997365,0.00002374043,0.00008517007,0.00004831768,0.00004818101,0.00005805574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001670885,0.000003146729,0.0002305575,0.000008049175,0.000001942224,0.00003026862,0.000004222237,0.00001197811,0.9993846,0.00004171095,0.000003586877,0.0002632643],"study_design_scores_gemma":[0.00002352165,0.0003356888,0.0807653,0.000009275827,0.00002995191,0.001327484,0.00008614684,0.001112064,0.9135858,0.0001208372,0.002592827,0.00001107153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964832,0.0006201035,0.002156849,0.00003890742,0.00001051294,0.000007870761,0.00008116251,0.00003063241,0.0005706401],"genre_scores_gemma":[0.9974463,0.0002576281,0.001196162,0.0000176517,0.000005001219,0.00001353542,0.0002466996,0.00001132426,0.0008056912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005803024,"threshold_uncertainty_score":0.002624273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343422772080435,"score_gpt":0.2504528730316976,"score_spread":0.2370186453108932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}