{"id":"W2099598799","doi":"10.1038/ng.941","title":"Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":416,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; Memorial University of Newfoundland","funders":"National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Münchner Zentrum für Gesundheitswissenschaften; Helmholtz Zentrum München; Tartu Ülikool; Medical Research Council; Canadian Cancer Society Research Institute; National Institutes of Health; Hjartavernd; Healthway; Tays; Novo Nordisk Fonden; AstraZeneca; European Commission; International Osteoporosis Foundation; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Asthma and Lung UK; Vetenskapsrådet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; East Midlands Development Agency; Novo Nordisk; Cambridge University Hospitals; British Heart Foundation; Bundesministerium für Bildung und Forschung; University of Cambridge; ZonMw; National Health and Medical Research Council; Oulun Yliopisto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Royal Society; University of Leicester; Erasmus Medisch Centrum; National Science Foundation; British Lung Foundation; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; National Cancer Institute; AXA Research Fund; Cancer Research UK; Wellcome Trust; Norges Teknisk-Naturvitenskapelige Universitet; European Regional Development Fund; King's College London; Jalmari ja Rauha Ahokkaan Säätiö; U.S. Public Health Service; Foundation for Cardiovascular Research; National Eye Institute; Biocenter, University of Oulu; National Institute for Health and Care Research; Flight Attendant Medical Research Institute; National Center for Research Resources; Nierstichting; University of Bristol; Directorate for Biological Sciences; GlaxoSmithKline; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation International","keywords":"Genome-wide association study; Pulmonary function testing; Vital capacity; Biology; Airway obstruction; Lung; Lung function; Genetics; Bioinformatics; Internal medicine; Medicine; Single-nucleotide polymorphism; Genotype; Airway; Gene; Diffusing capacity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009449237,0.0006141935,0.0006434221,0.001009563,0.0006895485,0.000872181,0.0007699511,0.001179696,0.001849384],"category_scores_gemma":[0.00205983,0.0003609338,0.001109823,0.0018092,0.0005330112,0.0003201978,0.000501213,0.000981305,0.0002909354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002328553,"about_ca_system_score_gemma":0.0002963275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003088021,"about_ca_topic_score_gemma":0.003714165,"domain_scores_codex":[0.9992574,0.0002055343,0.00006049575,0.0002799025,0.00009244351,0.0001041668],"domain_scores_gemma":[0.9981593,0.0009441981,0.0003764363,0.0002250236,0.00009580546,0.0001991523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002799591,0.0002509574,0.9429356,0.00005090142,0.0009184,0.001591818,0.0003669215,0.0003963473,0.03416466,0.0001689435,0.0005624034,0.01579355],"study_design_scores_gemma":[0.0000768739,0.0001464197,0.9965125,0.000005142956,0.0003042127,0.0008170418,0.00008205533,0.0003583262,0.001002714,0.0002198924,0.0004635755,0.00001126008],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99751,0.0005429924,0.0008764794,0.0001650536,0.0000216599,0.000008816347,0.0005140794,0.00002199189,0.0003390304],"genre_scores_gemma":[0.9982991,0.0001484448,0.00066145,0.00006080455,0.00002468287,0.00001338506,0.0003958592,0.00001387717,0.0003826048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003088021,"threshold_uncertainty_score":0.006186783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194303302691078,"score_gpt":0.2637124933437815,"score_spread":0.2517694603168707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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