{"id":"W2099598799","doi":"10.1038/ng.941","title":"Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":416,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; Memorial University of Newfoundland","funders":"National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Münchner Zentrum für Gesundheitswissenschaften; Helmholtz Zentrum München; Tartu Ülikool; Medical Research Council; Canadian Cancer Society Research Institute; National Institutes of Health; Hjartavernd; Healthway; Tays; Novo Nordisk Fonden; AstraZeneca; European Commission; International Osteoporosis Foundation; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Asthma and Lung UK; Vetenskapsrådet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; East Midlands Development Agency; Novo Nordisk; Cambridge University Hospitals; British Heart Foundation; Bundesministerium für Bildung und Forschung; University of Cambridge; ZonMw; National Health and Medical Research Council; Oulun Yliopisto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Royal Society; University of Leicester; Erasmus Medisch Centrum; National Science Foundation; British Lung Foundation; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; National Cancer Institute; AXA Research Fund; Cancer Research UK; Wellcome Trust; Norges Teknisk-Naturvitenskapelige Universitet; European Regional Development Fund; King's College London; Jalmari ja Rauha Ahokkaan Säätiö; U.S. Public Health Service; Foundation for Cardiovascular Research; National Eye Institute; Biocenter, University of Oulu; National Institute for Health and Care Research; Flight Attendant Medical Research Institute; National Center for Research Resources; Nierstichting; University of Bristol; Directorate for Biological Sciences; GlaxoSmithKline; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation International","keywords":"Genome-wide association study; Pulmonary function testing; Vital capacity; Biology; Airway obstruction; Lung; Lung function; Genetics; Bioinformatics; Internal medicine; Medicine; Single-nucleotide polymorphism; Genotype; Airway; Gene; Diffusing capacity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002981103,0.000189028,0.0002442407,0.0001597044,0.000143504,0.00004356028,0.0001075761,0.0004624664,0.0004442404],"category_scores_gemma":[0.0003626227,0.0001879104,0.0001011671,0.0002822119,0.00003968287,0.0001245075,0.0001314975,0.0007158428,0.00004005022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007832494,"about_ca_system_score_gemma":0.0002816404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004661995,"about_ca_topic_score_gemma":0.0001833774,"domain_scores_codex":[0.9981929,0.00005438111,0.0002456871,0.0004013616,0.0006533053,0.000452352],"domain_scores_gemma":[0.9988398,0.00006954426,0.0001232819,0.0003433595,0.0003261634,0.0002978514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002277833,0.00006293169,0.9839838,0.000247455,0.0002012769,0.00001964688,0.00124207,0.000003230334,0.00204632,0.00001844072,0.008033626,0.003913407],"study_design_scores_gemma":[0.001655598,0.00007046576,0.9789901,0.00004162677,0.0003010181,0.000007439985,0.0005456486,0.0002135851,0.001910987,0.0009837715,0.01510556,0.00017423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976302,0.01871995,0.0008478836,0.0002767729,0.0006309843,0.0004792469,0.0000249089,0.00006917987,0.002649022],"genre_scores_gemma":[0.9877676,0.0005221202,0.0006842374,0.0006148958,0.0005452616,0.00001089743,0.0001054569,0.00004297694,0.009706568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01819783,"threshold_uncertainty_score":0.7662764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194303302691078,"score_gpt":0.2637124933437815,"score_spread":0.2517694603168707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}