{"id":"W2099633227","doi":"10.2337/db11-0081","title":"Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Michael Smith Health Research BC; Canadian Diabetes Association; Killam Trusts; Heart and Stroke Foundation of Canada; Juvenile Diabetes Research Foundation International","keywords":"Exocytosis; Insulin; Internal medicine; Endocrinology; Granule (geology); ABCA1; Biology; Islet; Cell biology; Insulin oscillation; Secretion; Chemistry; Transporter; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036346,0.0001582776,0.0005272149,0.0002767188,0.00002430377,0.000005606292,0.0001028164,0.00008827017,0.000261592],"category_scores_gemma":[0.0004161216,0.0001375485,0.0001134135,0.0003692323,0.00006223237,0.0000856495,0.00004415375,0.00006181525,0.0001036023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002616782,"about_ca_system_score_gemma":0.00003313599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000742503,"about_ca_topic_score_gemma":0.000002807157,"domain_scores_codex":[0.99884,0.00004158371,0.0004198603,0.0002201343,0.0002309041,0.0002474913],"domain_scores_gemma":[0.9990087,0.0001143769,0.0001184792,0.0003630311,0.0001913698,0.0002040054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001961752,0.0002775587,0.6375915,0.0002324877,0.00007845934,0.000001764504,0.001643419,0.00001351154,0.3526405,0.00007923671,0.0005530472,0.006692386],"study_design_scores_gemma":[0.0007690035,0.0005152958,0.454887,0.0001657033,0.00006879928,5.605539e-7,0.00006206457,0.00006071434,0.5431678,0.00009558474,0.0001222654,0.00008524595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976158,0.0001044056,0.000125809,0.0002295377,0.0001166079,0.000419007,0.0000396393,0.00005391741,0.001295302],"genre_scores_gemma":[0.996964,0.000005242996,0.001843211,0.0009118254,0.00006489555,0.00004468704,0.00002871192,0.00002221976,0.0001151698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1905273,"threshold_uncertainty_score":0.5609066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04813748759354213,"score_gpt":0.2809957449171058,"score_spread":0.2328582573235636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}