{"id":"W2099633227","doi":"10.2337/db11-0081","title":"Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Michael Smith Health Research BC; Canadian Diabetes Association; Killam Trusts; Heart and Stroke Foundation of Canada; Juvenile Diabetes Research Foundation International","keywords":"Exocytosis; Insulin; Internal medicine; Endocrinology; Granule (geology); ABCA1; Biology; Islet; Cell biology; Insulin oscillation; Secretion; Chemistry; Transporter; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000262987,0.0008060372,0.0005047207,0.0005773376,0.0001920002,0.0006288682,0.0003432745,0.0004790999,0.001844369],"category_scores_gemma":[0.0003259071,0.0003546753,0.0004047613,0.0004405998,0.0005619004,0.0003090989,0.000479125,0.0008692725,0.0006390063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397174,"about_ca_system_score_gemma":0.0001795004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003185038,"about_ca_topic_score_gemma":0.0002897909,"domain_scores_codex":[0.9996688,0.00005036563,0.00006820679,0.00006460615,0.00009881729,0.00004919141],"domain_scores_gemma":[0.9995635,0.00007776504,0.0001968149,0.00006108239,0.00001892074,0.00008179614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004008576,0.00005151083,0.0006009204,0.00005212867,0.00001626898,0.0004987792,0.00001466645,0.00007258631,0.9969718,0.00008287594,0.00004233974,0.001195118],"study_design_scores_gemma":[0.0001770905,0.0003842383,0.01222411,0.00002037253,0.000114324,0.004048178,0.00005467398,0.00134638,0.9793476,0.0001868113,0.002082915,0.00001327855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962897,0.0008751856,0.001785411,0.0001111605,0.00002839571,0.00001838756,0.0001871931,0.00009368204,0.0006109952],"genre_scores_gemma":[0.9959528,0.0008033846,0.001509213,0.00005399688,0.0000141915,0.00003128147,0.0003480441,0.0000593128,0.001227582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844369,"threshold_uncertainty_score":0.006170034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04813748759354213,"score_gpt":0.2809957449171058,"score_spread":0.2328582573235636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}