{"id":"W2099635718","doi":"10.1091/mbc.e11-01-0054","title":"AP-1 and clathrin are essential for secretory granule biogenesis in<i>Drosophila</i>","year":2011,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Eye Institute","keywords":"Clathrin; Biology; Cell biology; Secretory protein; Granule (geology); Colocalization; Secretory pathway; Secretion; Golgi apparatus; Secretory Vesicle; Biogenesis; Drosophila melanogaster; Signal transducing adaptor protein; Endocytosis; Exocytosis; Signal transduction; Biochemistry; Endoplasmic reticulum; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009944978,0.0003077032,0.0001253848,0.0001853614,0.0003628349,0.00057806,0.0002662178,0.0002722125,0.0008205324],"category_scores_gemma":[0.0001541132,0.0002526148,0.000244981,0.00009981793,0.0002123489,0.0003349913,0.0003090176,0.0005370214,0.000634643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008405957,"about_ca_system_score_gemma":0.0003521805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002197677,"about_ca_topic_score_gemma":0.003095391,"domain_scores_codex":[0.9999082,0.000008213587,0.00001080914,0.00001867306,0.00003713446,0.00001689344],"domain_scores_gemma":[0.9998989,0.000008795706,0.00003823436,0.00001112724,0.00001367982,0.00002919514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008313422,0.000006596851,0.0005136981,0.00005048384,0.000006707308,0.0001122923,0.00001593862,0.00007050203,0.9963567,0.0003652694,0.000120348,0.002298421],"study_design_scores_gemma":[0.00003005021,0.00005966802,0.02946725,0.00002073112,0.00003459402,0.0008874106,0.00005093169,0.00193395,0.9569551,0.0004235885,0.01012214,0.00001467921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855461,0.004606382,0.006081937,0.0002482085,0.0000433475,0.00002205454,0.0005895159,0.0001907681,0.002671632],"genre_scores_gemma":[0.9879638,0.002244984,0.004080926,0.0001125153,0.00001276718,0.00002913797,0.001561397,0.00006509013,0.00392943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197677,"threshold_uncertainty_score":0.006098926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02765466782655902,"score_gpt":0.2638549311823277,"score_spread":0.2362002633557687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}