{"id":"W2099642935","doi":"10.1093/hmg/ddt625","title":"Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Huntingtin; Huntingtin Protein; Biology; Mutant; Förster resonance energy transfer; Phosphorylation; Cell biology; Biochemistry; Biophysics; Serine; Amino acid; Polyglutamine tract; Polyproline helix; Inclusion bodies; Mutant protein; Molecular biology; Fluorescence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322152,0.0002160206,0.0002201828,0.0001213544,0.0002129501,0.00006738769,0.0003034462,0.00003394164,0.0001681227],"category_scores_gemma":[0.0001990904,0.0002166601,0.00007845547,0.0001884237,0.0002887057,0.00003580069,0.0005311859,0.0001264098,0.00003688482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001344768,"about_ca_system_score_gemma":0.00005005387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005368368,"about_ca_topic_score_gemma":0.000002991113,"domain_scores_codex":[0.9981265,0.0004501179,0.0003292712,0.0005309418,0.000246429,0.0003167425],"domain_scores_gemma":[0.998978,0.0001173223,0.0001714332,0.0004661009,0.0001169626,0.0001501861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000001769333,0.00006872361,0.001019185,0.00002533165,0.000003217093,0.00001454255,0.0002506592,0.0002115836,0.9970971,0.0002042242,0.00003479382,0.001068915],"study_design_scores_gemma":[0.0003176601,0.00007508896,0.008665293,0.00001580108,0.00004366314,0.00001054493,0.00007033779,0.002039708,0.9863466,0.002124807,0.00008084702,0.0002096698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995679,0.001042037,0.001505672,0.00006151637,0.00007834105,0.0004276506,0.00001343719,0.00003170898,0.001160634],"genre_scores_gemma":[0.9770237,0.00007642605,0.02215146,0.0005605085,0.00002306422,0.00002696306,0.000002460779,0.00004553751,0.00008994528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02064579,"threshold_uncertainty_score":0.8835144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02035271282869647,"score_gpt":0.318373493645959,"score_spread":0.2980207808172625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}