{"id":"W2099642935","doi":"10.1093/hmg/ddt625","title":"Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Huntingtin; Huntingtin Protein; Biology; Mutant; Förster resonance energy transfer; Phosphorylation; Cell biology; Biochemistry; Biophysics; Serine; Amino acid; Polyglutamine tract; Polyproline helix; Inclusion bodies; Mutant protein; Molecular biology; Fluorescence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213545,0.0004220242,0.0002901968,0.0003360887,0.0002717289,0.0004780181,0.0005944674,0.00110616,0.0009092517],"category_scores_gemma":[0.0002609516,0.000212919,0.0002448547,0.0002845621,0.000661712,0.0004822184,0.0005030921,0.00084844,0.000628808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889283,"about_ca_system_score_gemma":0.0001798868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003140988,"about_ca_topic_score_gemma":0.0003609044,"domain_scores_codex":[0.9997038,0.00002057382,0.00001890468,0.0001139351,0.00009624477,0.00004633941],"domain_scores_gemma":[0.9997069,0.0001008036,0.00007118018,0.00004965908,0.0000318822,0.00003951811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004362579,0.00002081477,0.0001781719,0.00004571808,0.000003782198,0.0001580165,0.0000678888,0.00007003394,0.9964507,0.0007533204,0.00004921003,0.002158744],"study_design_scores_gemma":[0.00001482359,0.0001100838,0.004591969,0.00001553062,0.00001056965,0.001441762,0.00008031107,0.002654701,0.987491,0.0008432114,0.002732101,0.00001396681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8707902,0.003178824,0.1164838,0.0005479963,0.0001464263,0.0001182817,0.0007157737,0.0006786744,0.007339921],"genre_scores_gemma":[0.8757349,0.001777703,0.1151721,0.0004337461,0.00004345632,0.0003359539,0.0007223868,0.000106729,0.005673049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00110616,"threshold_uncertainty_score":0.003041685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02035271282869647,"score_gpt":0.318373493645959,"score_spread":0.2980207808172625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}