{"id":"W2099643741","doi":"10.1530/erc-11-0136","title":"IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer","year":2011,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Cancer Society Research Institute; McGill University; Terry Fox Research Institute; Joslin Diabetes Center","keywords":"Insulin receptor; Insulin; Hyperinsulinemia; Metformin; Endocrinology; Internal medicine; Tyrosine kinase; Medicine; Tyrosine-kinase inhibitor; Pharmacology; Cancer; Insulin resistance; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001248904,0.0004417606,0.0004636448,0.0001069175,0.00008545524,0.00001900133,0.0001576346,0.0002184935,0.000379662],"category_scores_gemma":[0.00001698695,0.0003253729,0.0001562823,0.0003092125,0.0001519697,0.00002722781,0.00005411982,0.000205535,0.000005766123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626599,"about_ca_system_score_gemma":0.0001324105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00328779,"about_ca_topic_score_gemma":0.0002215509,"domain_scores_codex":[0.9979616,0.0002422096,0.000468262,0.0006357504,0.0002341986,0.0004579738],"domain_scores_gemma":[0.9990773,0.00003211284,0.0002371247,0.0003871422,0.0001424955,0.0001238205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00169869,0.00076381,0.004550207,0.00003039237,0.0004624476,0.00002579068,0.005507045,0.00000693171,0.9086358,0.00001273637,0.002432436,0.07587373],"study_design_scores_gemma":[0.004846179,0.0008280453,0.01097718,0.0000912749,0.000125785,0.00002381087,0.0007114641,0.00003082719,0.9654464,0.00001606082,0.01652289,0.0003801274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8059106,0.1920935,0.000001466166,0.000214722,0.0002373624,0.0008012466,0.0006399021,0.00001482585,0.00008633086],"genre_scores_gemma":[0.9315425,0.06616621,0.00004476081,0.0005466407,0.0002112431,0.001067622,0.0002386081,0.00005310633,0.0001292883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1259273,"threshold_uncertainty_score":0.9999198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109815444200668,"score_gpt":0.2673072825757128,"score_spread":0.2562091281337062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}