{"id":"W2099647468","doi":"10.1067/mhj.2001.111262","title":"Active-control trials: How would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo","year":2001,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Placebo; Medicine; Aspirin; Clopidogrel; Odds ratio; Stroke (engine); Internal medicine; Confidence interval; Randomized controlled trial; Myocardial infarction; Anesthesia; Cardiology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.237956,0.003539869,0.009035189,0.004977202,0.001937384,0.008192403,0.003942794,0.008911809,0.007430169],"category_scores_gemma":[0.318613,0.001848374,0.004525232,0.003201112,0.01004849,0.0130676,0.002911568,0.01039499,0.001901878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002385072,"about_ca_system_score_gemma":0.003882298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119897,"about_ca_topic_score_gemma":0.001278854,"domain_scores_codex":[0.6753688,0.291693,0.01150886,0.007406412,0.01333441,0.000688545],"domain_scores_gemma":[0.7440028,0.229875,0.006605122,0.01200274,0.005990026,0.001524395],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.02628075,0.002115427,0.004292581,0.01917564,0.009664043,0.000371027,0.003205349,0.002960717,0.003317677,0.3061113,0.05976713,0.5627383],"study_design_scores_gemma":[0.03378382,0.006303289,0.003332303,0.005050097,0.006224763,0.0006723924,0.0007601886,0.02025698,0.002495924,0.8265156,0.09396302,0.0006416441],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.009299327,0.05554274,0.8160395,0.06817064,0.01610957,0.01936441,0.001583176,0.001151974,0.01273858],"genre_scores_gemma":[0.116215,0.01168588,0.7995306,0.02766224,0.007817836,0.03172758,0.0003493308,0.0003767222,0.004634774],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.762044,"threshold_uncertainty_score":0.9397359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04910941527731334,"score_gpt":0.3348498403598773,"score_spread":0.285740425082564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}