{"id":"W2099666962","doi":"10.1128/jb.01567-07","title":"The Type III Toxins of <i>Pseudomonas aeruginosa</i> Disrupt Epithelial Barrier Function","year":2007,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; University of Calgary","keywords":"Biology; Cell biology; Occludin; Tight junction; Cytochalasin D; Cytoskeleton; Actin cytoskeleton; Actin; Barrier function; Adherens junction; Microbiology; Cell; Cadherin; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007477469,0.0001230158,0.0002384706,0.00004559561,0.0001008578,0.000014864,0.0001644541,0.0002012189,0.00002392901],"category_scores_gemma":[0.0001374594,0.00008026498,0.0001574002,0.00007142658,0.000179357,0.000007295127,0.00006500485,0.0001573748,0.000003281482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000126919,"about_ca_system_score_gemma":0.0001004843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001134822,"about_ca_topic_score_gemma":0.0000406316,"domain_scores_codex":[0.9988923,0.0000843513,0.0005562181,0.0001237456,0.00009313057,0.0002502283],"domain_scores_gemma":[0.9988977,0.00005631942,0.000487202,0.0002009,0.0002700836,0.00008783712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002110255,0.00002563049,0.001388763,0.000003518514,0.00008881994,0.000007421657,0.0000288503,0.000002552158,0.9888463,0.00009327946,0.000445653,0.006958967],"study_design_scores_gemma":[0.0009287632,0.002107304,0.04114268,0.00001682404,0.00005568866,0.0004061438,0.0001305366,0.000001725858,0.758563,0.00005201487,0.1964532,0.000142049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961343,0.0004625683,0.0004017247,0.0001834109,0.002353633,0.00005615333,0.000007408167,0.000002359274,0.0003983827],"genre_scores_gemma":[0.9977616,0.0003055754,0.0002973382,0.0002227421,0.001198814,2.219188e-7,0.00001104064,0.00001316793,0.0001894971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2302832,"threshold_uncertainty_score":0.3273111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007394591417929963,"score_gpt":0.2353857768660859,"score_spread":0.227991185448156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}