{"id":"W2099678391","doi":"10.1158/1078-0432.ccr-06-1250","title":"Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; University of Pittsburgh","keywords":"Bioavailability; Pharmacokinetics; Pharmacology; Chemistry; In vivo; Catabolism; Cytidine; Metabolism; Metabolite; Oral administration; Deoxycytidine; Methyltransferase; Biochemistry; Enzyme; DNA; Biology; Medicine; Chemotherapy; Internal medicine; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003106618,0.000117599,0.000240911,0.00005929281,0.00006460359,0.00001734375,0.0002524016,0.000183367,0.00004033761],"category_scores_gemma":[0.0005257056,0.00008760708,0.0001099284,0.0003318441,0.0006793818,0.000004309861,0.0002030012,0.0003709712,0.000001542055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001999634,"about_ca_system_score_gemma":0.000194183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271051,"about_ca_topic_score_gemma":0.001530561,"domain_scores_codex":[0.9974813,0.0008557987,0.0005874007,0.0004455668,0.0003285393,0.0003013477],"domain_scores_gemma":[0.9990003,0.0002140285,0.00006677538,0.0003411825,0.0002913026,0.00008646756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002557281,0.0001973923,0.09888681,0.00002715493,0.00002305068,7.372304e-7,0.00001398623,0.00003871793,0.8930265,0.0000648749,0.0005222012,0.006942828],"study_design_scores_gemma":[0.001070926,0.0001221682,0.1677961,0.00001327651,0.00001937575,1.865735e-7,0.0000121832,0.00005223652,0.8113611,0.0005568687,0.01890314,0.00009237893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873558,0.01087773,0.00004585055,0.0008005567,0.0002290994,0.0003816126,0.00004772927,0.00000330578,0.0002582982],"genre_scores_gemma":[0.9951856,0.003799768,0.0002137137,0.00005715568,0.0004593155,0.00003655347,0.00001483082,0.00001707596,0.000216049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08166541,"threshold_uncertainty_score":0.3572513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08026696402152493,"score_gpt":0.4456804434732373,"score_spread":0.3654134794517123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}