{"id":"W2099678391","doi":"10.1158/1078-0432.ccr-06-1250","title":"Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; University of Pittsburgh","keywords":"Bioavailability; Pharmacokinetics; Pharmacology; Chemistry; In vivo; Catabolism; Cytidine; Metabolism; Metabolite; Oral administration; Deoxycytidine; Methyltransferase; Biochemistry; Enzyme; DNA; Biology; Medicine; Chemotherapy; Internal medicine; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003417545,0.0008379335,0.0005995659,0.00061156,0.0002468085,0.000492651,0.0003369406,0.0006651889,0.0006809663],"category_scores_gemma":[0.0001955255,0.0004337669,0.0005425422,0.000288432,0.0004162996,0.0004718537,0.0001040163,0.001232136,0.000514631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008141238,"about_ca_system_score_gemma":0.0004964042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001949093,"about_ca_topic_score_gemma":0.00174775,"domain_scores_codex":[0.9997138,0.00004512083,0.00001361435,0.00009061839,0.00007566815,0.00006119204],"domain_scores_gemma":[0.9997651,0.00003012628,0.00009519575,0.00002939861,0.00002530373,0.00005490865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002816763,0.0003301268,0.001120447,0.00003823128,0.00002362684,0.00003477438,0.00002958198,0.0003857033,0.9899435,0.00006673367,0.0002060535,0.005004488],"study_design_scores_gemma":[0.000239988,0.00779501,0.007953075,0.00000988307,0.00009948238,0.0002385951,0.00002493878,0.003204728,0.9777078,0.00007213359,0.002634549,0.00001976504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981321,0.005329074,0.008565231,0.0002900072,0.00007657892,0.0001452926,0.001921347,0.000516866,0.0018345],"genre_scores_gemma":[0.9805769,0.003138538,0.007046897,0.0002590722,0.00005021352,0.000288652,0.002315427,0.0001342298,0.006190002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949093,"threshold_uncertainty_score":0.00590694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08026696402152493,"score_gpt":0.4456804434732373,"score_spread":0.3654134794517123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}