{"id":"W2099687001","doi":"10.1084/jem.20110121","title":"High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling","year":2011,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; BC Cancer Agency","funders":"National Cancer Institute; Agence Nationale de la Recherche; Barbara Ann Karmanos Cancer Institute; Lawrence Foundation; Michael Smith Health Research BC; BC Children's Hospital; Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society; Cancer Research Society; Terry Fox Foundation; Bristol-Myers Squibb","keywords":"Insulin-like growth factor 1 receptor; Leukemia; Notch signaling pathway; Signal transduction; PI3K/AKT/mTOR pathway; Protein kinase B; Cancer research; Biology; Cell biology; Growth factor; Cell growth; Receptor; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463466,0.000222469,0.0002445336,0.0002518189,0.0002075276,0.0006003827,0.000215295,0.000190666,0.001167995],"category_scores_gemma":[0.0001853395,0.0001222303,0.0001304459,0.0001576818,0.0002973605,0.0002208023,0.0002832948,0.0005540789,0.000619008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004264861,"about_ca_system_score_gemma":0.0002528662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006143806,"about_ca_topic_score_gemma":0.0009718493,"domain_scores_codex":[0.9998282,0.00002604613,0.00002531865,0.00002397647,0.00005037472,0.00004609609],"domain_scores_gemma":[0.9997945,0.00002364744,0.00006768638,0.00003040454,0.00001455271,0.00006923498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001156313,0.00001985874,0.0007766364,0.00001778826,0.000002033366,0.00009149738,0.00001139934,0.00004887536,0.9973295,0.0001713646,0.00003886214,0.001376598],"study_design_scores_gemma":[0.00002324414,0.0003206745,0.02016314,0.000007948412,0.00001757335,0.0008936811,0.00008036566,0.0006178637,0.9744653,0.0001236015,0.003280009,0.000006754155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951331,0.001098128,0.001291936,0.00008935827,0.00001505355,0.0000159046,0.00045363,0.0001203352,0.001782515],"genre_scores_gemma":[0.997509,0.0003899173,0.0007365645,0.00002407034,0.000006955394,0.00001379382,0.0005328844,0.00001500581,0.0007717941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167995,"threshold_uncertainty_score":0.003907263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09934782191625087,"score_gpt":0.3489146602882922,"score_spread":0.2495668383720413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}