{"id":"W2099687001","doi":"10.1084/jem.20110121","title":"High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling","year":2011,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; BC Cancer Agency","funders":"National Cancer Institute; Agence Nationale de la Recherche; Barbara Ann Karmanos Cancer Institute; Lawrence Foundation; Michael Smith Health Research BC; BC Children's Hospital; Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society; Cancer Research Society; Terry Fox Foundation; Bristol-Myers Squibb","keywords":"Insulin-like growth factor 1 receptor; Leukemia; Notch signaling pathway; Signal transduction; PI3K/AKT/mTOR pathway; Protein kinase B; Cancer research; Biology; Cell biology; Growth factor; Cell growth; Receptor; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001332681,0.0002509877,0.0006278664,0.0002009257,0.0001056058,0.000008422527,0.0002430667,0.0001382534,0.0004681887],"category_scores_gemma":[0.0002316034,0.0001510901,0.0000765852,0.0001697844,0.0002694169,0.0002343871,0.0001135006,0.0004538377,0.000002589126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007184669,"about_ca_system_score_gemma":0.0003091118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005029485,"about_ca_topic_score_gemma":0.000001481901,"domain_scores_codex":[0.9977476,0.0001394038,0.0007265604,0.0002204292,0.0007378389,0.0004281967],"domain_scores_gemma":[0.9981468,0.0006148276,0.0005126538,0.0002518263,0.0001691594,0.000304754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003637306,0.0002326359,0.0002284911,0.00007288986,0.00006453716,0.00007358719,0.01785975,3.879273e-7,0.9624966,0.000002328296,0.01470113,0.0006303872],"study_design_scores_gemma":[0.01320863,0.002895703,0.0004388178,0.0007481572,0.0001355797,0.0002998662,0.007135967,0.0005485002,0.9742273,0.00006955123,0.0001561157,0.0001357916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944153,0.001485427,0.001483239,0.001440169,0.0001807446,0.000511974,0.00002168968,0.00001069866,0.0004507689],"genre_scores_gemma":[0.9946269,0.0001760443,0.002943205,0.001614125,0.0003325091,0.00001358062,0.000007647402,0.00004462319,0.0002414132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01454501,"threshold_uncertainty_score":0.6161274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09934782191625087,"score_gpt":0.3489146602882922,"score_spread":0.2495668383720413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}