{"id":"W2099720065","doi":"10.1136/bjo.2007.123125","title":"Hypoxia-inducible factor expression in human RPE cells","year":2007,"lang":"en","type":"article","venue":"British Journal of Ophthalmology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Messenger RNA; Western blot; Hypoxia-inducible factors; Vascular endothelial growth factor; Erythropoietin; Molecular biology; Hypoxia (environmental); Gene silencing; Biology; G alpha subunit; Retinal pigment epithelium; Angiogenesis; Vascular endothelial growth factor A; Reverse transcription polymerase chain reaction; HIF1A; Retinal; Endocrinology; Chemistry; Biochemistry; Cancer research; VEGF receptors; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004366544,0.0002519817,0.0002948778,0.0002495167,0.0001958457,0.0003830715,0.0001777079,0.0003404441,0.00248784],"category_scores_gemma":[0.0002983775,0.0001164707,0.0003081432,0.0003575738,0.0001864756,0.0001841115,0.0002031231,0.0004926024,0.001435629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002901974,"about_ca_system_score_gemma":0.000204619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007005262,"about_ca_topic_score_gemma":0.0005423808,"domain_scores_codex":[0.9996098,0.00006615092,0.00005174445,0.00007943518,0.0001471852,0.0000457645],"domain_scores_gemma":[0.9998379,0.00004272867,0.00002894662,0.00003139631,0.00004873549,0.00001021013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001078707,0.00003488966,0.0002250564,0.0001837473,0.00001258609,0.0001234464,0.00006314478,0.00009499706,0.9934402,0.0002061261,0.0003656584,0.00514229],"study_design_scores_gemma":[0.00004481702,0.0005660353,0.008470312,0.00005143862,0.00007215516,0.001128318,0.00007497262,0.001160847,0.9443236,0.0001707304,0.04392175,0.00001500651],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8716763,0.03827183,0.05632868,0.0009332034,0.0005211155,0.0006742619,0.007703924,0.0007712245,0.02311944],"genre_scores_gemma":[0.9335366,0.01258928,0.02915422,0.0004526135,0.0001132949,0.0007052606,0.007876842,0.0001017099,0.0154701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00248784,"threshold_uncertainty_score":0.008322656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913386270300287,"score_gpt":0.290207939719083,"score_spread":0.2710740770160801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}