{"id":"W2099733570","doi":"10.1371/journal.pgen.1001371","title":"Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Human Genome Research Institute; Broad Institute; University of California, Irvine; U.S. Army; U.S. Department of Defense; U.S. Public Health Service; University of Illinois at Urbana-Champaign; Kenneth T. and Eileen L. Norris Foundation; National Institutes of Health; Wellcome Trust; University of Minnesota; Case Western Reserve University; Johns Hopkins University; University of Washington; National Heart, Lung, and Blood Institute; University of Miami; Northwestern University; Jackson State University; Medical Research and Materiel Command; Kaiser Foundation Research Institute; National Cancer Institute; Wake Forest University; Ministerio de Economía y Competitividad; Breast Cancer Research Foundation; University of Pittsburgh; University of North Carolina at Chapel Hill","keywords":"Genome-wide association study; Linkage disequilibrium; Imputation (statistics); Biology; Single-nucleotide polymorphism; Ancestry-informative marker; SNP; Genetic association; Genetic genealogy; Genetics; Statistical power; Locus (genetics); Population stratification; Population; Statistics; Demography; Genotype; Missing data; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1074119,0.0009398884,0.001527218,0.002587288,0.001201905,0.00177074,0.002355034,0.001670473,0.002802018],"category_scores_gemma":[0.3117519,0.0005244631,0.002135562,0.003832208,0.002035463,0.001899373,0.003344814,0.002366869,0.0002825538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005422051,"about_ca_system_score_gemma":0.001819475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002255212,"about_ca_topic_score_gemma":0.003312281,"domain_scores_codex":[0.8824151,0.1022325,0.003125783,0.005158545,0.006237722,0.0008304884],"domain_scores_gemma":[0.6634506,0.2896011,0.01318003,0.02351126,0.008041632,0.002215457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00309474,0.0005070857,0.5361213,0.0009605755,0.009134783,0.002478322,0.002758449,0.06303569,0.007389186,0.0309201,0.007048455,0.3365513],"study_design_scores_gemma":[0.001057151,0.002225419,0.3187118,0.0003345935,0.002314065,0.002975697,0.000943962,0.5838029,0.007402,0.06645204,0.01350039,0.0002800202],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2495174,0.001432182,0.7433235,0.001537232,0.0001791393,0.0004542469,0.0006318158,0.000914343,0.002010173],"genre_scores_gemma":[0.6699964,0.0002011286,0.3271877,0.0005060207,0.0001199379,0.0006553243,0.0006045196,0.0002134868,0.0005154434],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1074119,"threshold_uncertainty_score":0.5680553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07976579191052348,"score_gpt":0.3593942542925467,"score_spread":0.2796284623820232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}