{"id":"W2099733570","doi":"10.1371/journal.pgen.1001371","title":"Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Human Genome Research Institute; Broad Institute; University of California, Irvine; U.S. Army; U.S. Department of Defense; U.S. Public Health Service; University of Illinois at Urbana-Champaign; Kenneth T. and Eileen L. Norris Foundation; National Institutes of Health; Wellcome Trust; University of Minnesota; Case Western Reserve University; Johns Hopkins University; University of Washington; National Heart, Lung, and Blood Institute; University of Miami; Northwestern University; Jackson State University; Medical Research and Materiel Command; Kaiser Foundation Research Institute; National Cancer Institute; Wake Forest University; Ministerio de Economía y Competitividad; Breast Cancer Research Foundation; University of Pittsburgh; University of North Carolina at Chapel Hill","keywords":"Genome-wide association study; Linkage disequilibrium; Imputation (statistics); Biology; Single-nucleotide polymorphism; Ancestry-informative marker; SNP; Genetic association; Genetic genealogy; Genetics; Statistical power; Locus (genetics); Population stratification; Population; Statistics; Demography; Genotype; Missing data; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000632293,0.0001480246,0.0002337251,0.00003899977,0.00007057204,0.000009573396,0.0000886042,0.0001280756,0.00003089144],"category_scores_gemma":[0.00009341814,0.0001526599,0.00003500961,0.00006958021,0.00009750552,0.000001953701,0.00006484782,0.00006519358,4.818334e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005588186,"about_ca_system_score_gemma":0.000172856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004745066,"about_ca_topic_score_gemma":0.001568759,"domain_scores_codex":[0.9988953,0.00009151884,0.0002994504,0.000360785,0.00007392352,0.0002790099],"domain_scores_gemma":[0.9993797,0.00005070324,0.0001339288,0.0002004437,0.0001385329,0.00009668896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007380325,0.0001616985,0.8224288,0.00002815388,0.0001099361,0.000001247548,0.0007030253,0.0004337249,0.1700803,0.00009580678,0.000100888,0.005782614],"study_design_scores_gemma":[0.0007897519,0.0002962137,0.9786007,0.00002355949,0.0001370848,0.000002692187,0.001103504,0.007262369,0.0105032,0.0008345966,0.0001433495,0.0003029134],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97435,0.0008291781,0.02321675,0.00005493625,0.00008530119,0.0003520296,0.0009624977,0.000006724887,0.0001425649],"genre_scores_gemma":[0.9004503,0.0002107848,0.09873509,0.0001151357,0.00009099157,0.0001253342,0.0002410017,0.00002180811,0.000009504901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1595771,"threshold_uncertainty_score":0.6225289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07976579191052348,"score_gpt":0.3593942542925467,"score_spread":0.2796284623820232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}