{"id":"W2099739812","doi":"10.1002/cbic.200800249","title":"Isofagomine Induced Stabilization of Glucocerebrosidase","year":2008,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Mutant; Hydrogen bond; Stereochemistry; Biochemistry; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007837276,0.0001044947,0.0002337844,0.0000855593,0.00004485521,0.000002821971,0.0000869968,0.000101974,0.0003953805],"category_scores_gemma":[0.0003776223,0.00009606911,0.00007657574,0.0003857367,0.0001160146,0.00005107868,0.00005143111,0.0001242227,0.00004616526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000690201,"about_ca_system_score_gemma":0.000162671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004419122,"about_ca_topic_score_gemma":0.000002001561,"domain_scores_codex":[0.999031,0.00001279122,0.0002151459,0.0002043465,0.0003387803,0.0001979555],"domain_scores_gemma":[0.9992059,0.00002773711,0.000059055,0.0003196016,0.0002600169,0.0001277289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477134,0.0003346724,0.02579492,0.0001617349,0.00002615515,0.00002236739,0.000442556,3.062579e-7,0.9709466,0.00004255792,0.001089119,0.0009912938],"study_design_scores_gemma":[0.0015487,0.0001970498,0.0253259,0.0000304774,0.00001447025,0.00005819518,0.0001230997,0.00008149488,0.9722218,0.00001436295,0.0002999045,0.00008455601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926319,0.0002440064,0.00006652733,0.0002390304,0.00002918782,0.0002707076,0.000003444564,0.00004575127,0.00646949],"genre_scores_gemma":[0.9982997,0.00005197094,0.0002804658,0.00009001994,0.00005476599,0.00001309487,0.00004885258,0.00002257051,0.001138594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005667812,"threshold_uncertainty_score":0.432914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05180956846908807,"score_gpt":0.3027084350162453,"score_spread":0.2508988665471572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}