{"id":"W2099755355","doi":"10.1101/gr.132662.111","title":"Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression","year":2012,"lang":"en","type":"article","venue":"Genome Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":536,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health","keywords":"DNA methylation; Biology; Adenocarcinoma; Epigenetics; Methylation; Cancer research; Lung cancer; KRAS; Epigenomics; Gene; Cancer; Genetics; Gene expression; Colorectal cancer; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576512,0.0001256285,0.0001614968,0.0004587168,0.0001322014,0.0001684454,0.0001018732,0.0001191058,0.0005521988],"category_scores_gemma":[0.0002354555,0.00009462183,0.0001968929,0.0004309667,0.0001017997,0.00005785168,0.0002072184,0.0001883625,0.0001750553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001599029,"about_ca_system_score_gemma":0.0001492246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002356013,"about_ca_topic_score_gemma":0.004377024,"domain_scores_codex":[0.9998379,0.00002214228,0.0000057056,0.00006596333,0.00004645528,0.00002181913],"domain_scores_gemma":[0.9999199,0.00001926498,0.00002313915,0.00001117307,0.0000157184,0.0000107878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001954425,0.00001351506,0.04333892,0.00005211776,0.00009896752,0.00004600877,0.00006746817,0.0002612896,0.944671,0.00006706326,0.00009950726,0.01108854],"study_design_scores_gemma":[0.000009433285,0.0001563543,0.8313038,0.000005162737,0.0001124725,0.0003286827,0.00006976286,0.002440038,0.1631387,0.0001513604,0.00227191,0.00001239134],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888081,0.001152979,0.006192277,0.00004305206,0.000006573887,0.00002246791,0.002777565,0.00009333684,0.0009036174],"genre_scores_gemma":[0.9884248,0.0004255256,0.006077964,0.00005557514,0.0000050452,0.00003632959,0.00400009,0.00002673567,0.0009479839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002356013,"threshold_uncertainty_score":0.004684567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0338198380818476,"score_gpt":0.3362047196645843,"score_spread":0.3023848815827367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}