{"id":"W2099769818","doi":"10.1083/jcb.201208083","title":"Fixing cystic fibrosis by correcting CFTR domain assembly","year":2012,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Cystic fibrosis; Biology; Chloride channel; Cystic fibrosis transmembrane conductance regulator; Secretion; Disease; Mutation; Cell biology; Mechanism (biology); Function (biology); Computational biology; Cell; Bioinformatics; Gene; Genetics; Internal medicine; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004387042,0.0004798003,0.0003635203,0.0005677899,0.0004794007,0.0005498792,0.0004736104,0.0007868879,0.002309729],"category_scores_gemma":[0.0008087981,0.0002484074,0.000373095,0.0002553843,0.0006749742,0.0004932391,0.0005777282,0.001528787,0.001360969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003986702,"about_ca_system_score_gemma":0.0004130969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006604315,"about_ca_topic_score_gemma":0.0007153425,"domain_scores_codex":[0.9997999,0.00002962943,0.00001643311,0.0000359979,0.00008078438,0.00003726041],"domain_scores_gemma":[0.9997272,0.00005342291,0.00006449308,0.00004719332,0.00005184656,0.00005582012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468255,0.00009416055,0.0005372182,0.000312483,0.00002602462,0.000293785,0.00009838942,0.0005618882,0.9323208,0.005422652,0.005031524,0.05515426],"study_design_scores_gemma":[0.00008611708,0.0006597964,0.001704488,0.0001226989,0.00008010279,0.002757295,0.0001093592,0.002191056,0.8455702,0.004768442,0.1419102,0.00004026984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6923212,0.1021877,0.1371514,0.02270667,0.00838308,0.0003799548,0.0007749364,0.00598018,0.03011487],"genre_scores_gemma":[0.8673465,0.04583598,0.06419837,0.005073171,0.0008098736,0.000147335,0.0004807173,0.0004545212,0.01565341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309729,"threshold_uncertainty_score":0.007726848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409337152653892,"score_gpt":0.3058580749864369,"score_spread":0.2917647034598979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}