{"id":"W2099836262","doi":"10.1016/j.cardiores.2004.01.029","title":"The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents","year":2004,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Wortmannin; Contractility; LY294002; Myocyte; Internal medicine; Patch clamp; Endocrinology; Phosphoinositide 3-kinase; Chemistry; Biology; Biophysics; Phosphatidylinositol; PI3K/AKT/mTOR pathway; Medicine; Cell biology; Electrophysiology; Kinase; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386092,0.0004706956,0.0002906642,0.0001383347,0.0001302672,0.0002045995,0.0002670023,0.0002442102,0.001592373],"category_scores_gemma":[0.0001173824,0.00008918912,0.0002579134,0.000109001,0.0002232403,0.0002869646,0.0001986937,0.0005831534,0.0003697341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002335967,"about_ca_system_score_gemma":0.0002293302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002869865,"about_ca_topic_score_gemma":0.0006473128,"domain_scores_codex":[0.9999213,0.00001003138,0.000009460397,0.00001617803,0.00002554098,0.00001749671],"domain_scores_gemma":[0.9999377,0.00001317645,0.00001430525,0.000005830001,0.000007741864,0.00002129517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001323876,0.0000406759,0.00005902756,0.00004780768,0.000003632595,0.00003457225,0.000005843568,0.00003804529,0.9984676,0.00002549519,0.00003097926,0.001113864],"study_design_scores_gemma":[0.00008376263,0.000815313,0.005101148,0.000007056908,0.0000175326,0.0001312904,0.00001556235,0.001371048,0.9911513,0.00004245171,0.001260194,0.000003390472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899838,0.003133073,0.003314751,0.0002052949,0.00007381453,0.00005778114,0.0003938329,0.0001658062,0.002671867],"genre_scores_gemma":[0.9930524,0.001867512,0.002379519,0.00007688875,0.00003757132,0.00006524804,0.0003248816,0.00001982579,0.002176156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592373,"threshold_uncertainty_score":0.005326986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268472752200276,"score_gpt":0.3124394660034169,"score_spread":0.2897547384814141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}