{"id":"W2099854994","doi":"10.4049/jimmunol.1003081","title":"Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":569,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Wellcome Trust","keywords":"TIGIT; T cell; Autoimmunity; CD80; Cell biology; Immunology; CD28; Biology; Cancer research; Immune system; Cytotoxic T cell; In vitro; CD40; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006202161,0.0001686406,0.0002834062,0.0002453674,0.000461089,0.00001395788,0.0003676077,0.0002297476,0.003832997],"category_scores_gemma":[0.0001161471,0.0001138493,0.0001840907,0.0001540672,0.000437027,0.0002442783,0.00009652844,0.001074403,0.002264487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007276789,"about_ca_system_score_gemma":0.0001243616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008023013,"about_ca_topic_score_gemma":0.000003958402,"domain_scores_codex":[0.9984195,0.0004902469,0.0006369285,0.0001062706,0.00003963381,0.0003074201],"domain_scores_gemma":[0.9985219,0.0002091707,0.0006547887,0.0003086769,0.0002889207,0.00001654623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001586371,0.0003232087,0.0004926542,0.000007333214,0.0005334729,0.000009727219,0.003351016,0.00000489129,0.9031031,0.0001937119,0.07956275,0.01083177],"study_design_scores_gemma":[0.002001004,0.001417801,0.007011622,0.00004731544,0.0002470129,0.003440112,0.005180372,0.00000119894,0.503121,0.0001580141,0.4771694,0.0002051207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9177457,0.01817022,0.001757422,0.0007411608,0.02824729,0.0001840234,0.000001746609,0.00007586827,0.03307655],"genre_scores_gemma":[0.9817717,0.0003933377,0.00004390251,0.0002609629,0.0001506116,0.000002520401,0.000005695347,0.00001939356,0.01735187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3999821,"threshold_uncertainty_score":0.9985124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02581069071281808,"score_gpt":0.2115990943713296,"score_spread":0.1857884036585115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}