{"id":"W2099866950","doi":"10.1038/ni.1979","title":"Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5","year":2011,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":802,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Universität Heidelberg; Medical Research Council; Deutsche Forschungsgemeinschaft; European Commission; Wellcome Trust; Institute of Genetics; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Biotechnology and Biological Sciences Research Council; Austrian Science Fund; Imperial College London; National Science Foundation","keywords":"Methylation; RNA; Biology; Methyltransferase; Messenger RNA; RNA methylation; Molecular biology; Interferon; Cytoplasm; Cell biology; Gene; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511588,0.0002254484,0.0001508125,0.000159314,0.0001454695,0.0003074973,0.0002232782,0.0003035982,0.001114203],"category_scores_gemma":[0.0002051381,0.0001826419,0.000215963,0.00009022884,0.0002760479,0.0003484248,0.0002450039,0.0004417238,0.0004376263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758371,"about_ca_system_score_gemma":0.0001245804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005571688,"about_ca_topic_score_gemma":0.001079143,"domain_scores_codex":[0.9998894,0.00001725848,0.000004207804,0.00003506709,0.000026291,0.00002775279],"domain_scores_gemma":[0.9998659,0.00002591356,0.00004199509,0.00002278713,0.00001630364,0.00002714077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005362926,0.000002438707,0.0002842223,0.000007972122,0.00000218785,0.00002119239,0.00001234046,0.00003059374,0.9984881,0.0002357049,0.00002137613,0.0008402379],"study_design_scores_gemma":[0.00000300592,0.00005995173,0.004325807,0.000002549423,0.000005629084,0.000103961,0.00002144763,0.0005512417,0.9940467,0.0001456738,0.0007293092,0.000004772051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876474,0.0009446381,0.008508256,0.00013767,0.00003632346,0.000009233602,0.0001916623,0.0001334119,0.002391319],"genre_scores_gemma":[0.9964098,0.0001872238,0.002095197,0.00006716548,0.000007574023,0.000004218679,0.0001930012,0.00002246385,0.001013366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114203,"threshold_uncertainty_score":0.003727317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008543444517332889,"score_gpt":0.2292237923625621,"score_spread":0.2206803478452292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}