{"id":"W2099876732","doi":"10.2174/1567205012666141218124243","title":"No Significant Effect of 7,8-Dihydroxyflavone on APP Processing and Alzheimer-Associated Phenotypes","year":2015,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Neuropathology; Neuroscience; Psychology; Excitotoxicity; Senile plaques; Alzheimer's disease; Disease; Medicine; NMDA receptor; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00147536,0.0002042867,0.0002477612,0.000160746,0.000141029,0.00005480114,0.0002719424,0.0001414603,0.00002263176],"category_scores_gemma":[0.001027392,0.0001719838,0.00007066833,0.0002642505,0.0002990479,0.00001200019,0.0002399921,0.0004411661,0.0001129595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002420164,"about_ca_system_score_gemma":0.0001904691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000609137,"about_ca_topic_score_gemma":0.000008247141,"domain_scores_codex":[0.9976889,0.0005233762,0.0002646811,0.0004874154,0.0005835944,0.0004520381],"domain_scores_gemma":[0.9985233,0.0001200804,0.0001133623,0.0003700962,0.0006450386,0.0002281335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002493029,0.001241721,0.006501656,0.0001970968,0.001660209,0.000009176252,0.0004794215,0.00006164583,0.7669625,0.000130544,0.03619344,0.1840696],"study_design_scores_gemma":[0.001761596,0.003783524,0.0005569598,0.0002653246,0.0002304958,0.000004439707,0.00006688206,0.0006182569,0.9533477,0.0001175166,0.03887221,0.0003750833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549003,0.0389211,0.0000510835,0.0001498592,0.0004284606,0.00114966,0.0000359289,0.00003994007,0.004323647],"genre_scores_gemma":[0.9991082,0.0001512525,0.00006355102,0.000008897807,0.0002446765,0.0001352949,0.0001003797,0.00003867443,0.0001491065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1863853,"threshold_uncertainty_score":0.7013294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129346191616961,"score_gpt":0.4213075319984245,"score_spread":0.2919613403814636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}