{"id":"W2099895966","doi":"10.1209/epl/i2003-10289-5","title":"Conformational conversion of proteins due to mutation","year":2004,"lang":"en","type":"article","venue":"Europhysics Letters (EPL)","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Monomer; Monte Carlo method; Hydrogen bond; Protein secondary structure; Free energy perturbation; Sequence (biology); Helix (gastropod); Chemistry; Kinetics; Thermodynamics; Chemical physics; Physics; Molecular dynamics; Computational chemistry; Molecule; Biology; Biochemistry; Polymer; Classical mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003764903,0.00009902495,0.00009179209,0.00003209782,0.0000428922,0.00001039611,0.0001175731,0.00004162416,0.000003804322],"category_scores_gemma":[0.00001950282,0.00009966362,0.00005430873,0.00008743008,0.00004602494,0.000007772092,0.00005660911,0.00005588836,0.00002609642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001499413,"about_ca_system_score_gemma":0.00004221085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001464548,"about_ca_topic_score_gemma":9.187475e-7,"domain_scores_codex":[0.9994194,0.00001680565,0.0001445186,0.0001554425,0.000143743,0.0001200801],"domain_scores_gemma":[0.9996089,0.00000327297,0.00008076159,0.0001898738,0.00007144004,0.00004572561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005229766,0.00001842119,0.00002622382,0.0000266059,0.00001688324,0.000008192319,0.0001153352,0.004286132,0.9932334,0.00146725,0.0002032208,0.0005460625],"study_design_scores_gemma":[0.0006809278,0.0002468243,0.00156359,0.00001604564,0.000009835322,0.00001677726,0.00001685742,0.00006744877,0.9937868,0.0005756738,0.002851753,0.0001674669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8767135,0.000009550538,0.1219361,0.0006328697,0.00009503595,0.0002364494,0.0000248263,0.000009103401,0.0003426027],"genre_scores_gemma":[0.991128,0.000001774653,0.005710307,0.002783715,0.0001521638,0.00000967595,0.0001775628,0.00001369508,0.00002306303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1162257,"threshold_uncertainty_score":0.4064164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00336551043884422,"score_gpt":0.19673535533742,"score_spread":0.1933698448985758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}