{"id":"W2099911321","doi":"10.1093/jnci/djq363","title":"Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study","year":2010,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK","keywords":"CDKN2A; Melanocortin 1 receptor; Melanoma; Germline mutation; Penetrance; Genetics; Odds ratio; Biology; Phenotype; Mutation; Cancer research; Medicine; Cancer; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006162086,0.00007566968,0.000184187,0.0001938038,0.00006995885,0.00001697748,0.00007442861,0.00004501633,0.00003805284],"category_scores_gemma":[0.000376116,0.00004973683,0.00004094507,0.0002384548,0.00003855322,0.0001499212,0.00002106208,0.0003147068,6.718814e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003202125,"about_ca_system_score_gemma":0.0003154643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004097953,"about_ca_topic_score_gemma":0.006238153,"domain_scores_codex":[0.9988242,0.00004532686,0.0003131669,0.00008931693,0.0006495907,0.00007838733],"domain_scores_gemma":[0.9987195,0.00004683076,0.0006043141,0.00006317109,0.0005203119,0.00004592139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001935804,0.0006453855,0.9698676,0.00007442071,0.001250171,0.0000970199,0.004018356,0.00220809,0.0120879,0.0004429097,0.0008046912,0.006567659],"study_design_scores_gemma":[0.003709929,0.0004514075,0.9898204,0.00006547978,0.000311714,0.0002496066,0.0003865253,0.0002503256,0.000606531,0.0001653594,0.003911078,0.0000715988],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996874,0.00006014559,0.0000515485,0.0009173303,0.00106462,0.0003169997,0.00001771127,0.000003652706,0.0006940339],"genre_scores_gemma":[0.9987819,0.00004220789,0.0003074421,0.0001299171,0.0003213771,0.000008023377,8.225473e-7,0.000006454609,0.0004018157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01995286,"threshold_uncertainty_score":0.3481036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407557187141285,"score_gpt":0.2801200402529628,"score_spread":0.2660444683815499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}