{"id":"W2099911321","doi":"10.1093/jnci/djq363","title":"Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study","year":2010,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK","keywords":"CDKN2A; Melanocortin 1 receptor; Melanoma; Germline mutation; Penetrance; Genetics; Odds ratio; Biology; Phenotype; Mutation; Cancer research; Medicine; Cancer; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007369164,0.0005628416,0.0004525401,0.001150221,0.0007098267,0.0004867347,0.0005452018,0.0007542989,0.003043901],"category_scores_gemma":[0.002008609,0.0004127841,0.0007073494,0.001166575,0.0004526053,0.0003348243,0.0005667196,0.0004769512,0.0002822697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003779402,"about_ca_system_score_gemma":0.0002977937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01121271,"about_ca_topic_score_gemma":0.006976288,"domain_scores_codex":[0.9994075,0.0001739067,0.00004143963,0.0002256381,0.00007132273,0.00008015024],"domain_scores_gemma":[0.999088,0.0003281255,0.0002689195,0.0001125488,0.00005817211,0.0001442419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005256477,0.0001027616,0.9944056,0.00001835659,0.0003068036,0.0008492421,0.0002822106,0.0001154501,0.001729751,0.00004989876,0.0001056236,0.001508573],"study_design_scores_gemma":[0.0000392619,0.0001714577,0.9974952,0.000006087208,0.0001804982,0.001197017,0.0001323298,0.0003858012,0.0001678974,0.00003576286,0.0001822867,0.000006485054],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995327,0.00007009616,0.0001025658,0.0000119845,0.000001037445,0.000006536544,0.0001670875,0.000002978423,0.0001049305],"genre_scores_gemma":[0.9994778,0.00004945598,0.0001536867,0.00001216625,0.000003338459,0.000007689069,0.0002003711,0.00000317843,0.00009231974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01121271,"threshold_uncertainty_score":0.02229488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407557187141285,"score_gpt":0.2801200402529628,"score_spread":0.2660444683815499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}