{"id":"W2099921758","doi":"10.1074/jbc.m102453200","title":"Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1)","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Glutathione; Glucuronide; Chemistry; Metabolite; Biochemistry; Multidrug resistance-associated protein 2; Mediated transport; Carcinogen; Glucuronidation; Leukotriene C4; ABCC1; Metabolism; ATP-binding cassette transporter; Transporter; In vitro; Biology; Microsome; Enzyme; Leukotriene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007725662,0.0002904052,0.000711553,0.00001951459,0.0001637785,0.000008451267,0.0009143341,0.0002694971,0.000213372],"category_scores_gemma":[0.0001207291,0.0001162954,0.000768973,0.0003671892,0.0008102955,0.00004453866,0.00004401932,0.0008471566,0.000001030281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008307296,"about_ca_system_score_gemma":0.0001893462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104997,"about_ca_topic_score_gemma":0.000009689652,"domain_scores_codex":[0.9973977,0.0001088741,0.001149988,0.0002643516,0.0007166934,0.0003624349],"domain_scores_gemma":[0.9977301,0.0001128856,0.001034331,0.00065468,0.0003298786,0.0001381232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001149653,0.0002502432,0.03399462,0.0001143673,0.0001064999,0.00005512314,0.0001274048,0.00000575337,0.9634464,0.00003603333,0.0004160743,0.0002978196],"study_design_scores_gemma":[0.001319004,0.0001010472,0.0449291,0.000451891,0.0001259635,0.0001436728,0.0004210615,0.00000230693,0.9318546,0.0002604043,0.02025021,0.000140743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915178,0.003537491,0.0001110705,0.002723352,0.0001458341,0.0004880773,0.0001113596,0.00001101519,0.001353929],"genre_scores_gemma":[0.9958732,0.0006050724,0.000264613,0.0001624424,0.0001908561,0.00001113268,0.000008888585,0.00001976016,0.002864022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03159181,"threshold_uncertainty_score":0.474239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774008556070168,"score_gpt":0.2254376353451178,"score_spread":0.2076975497844161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}