{"id":"W2099921758","doi":"10.1074/jbc.m102453200","title":"Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1)","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Glutathione; Glucuronide; Chemistry; Metabolite; Biochemistry; Multidrug resistance-associated protein 2; Mediated transport; Carcinogen; Glucuronidation; Leukotriene C4; ABCC1; Metabolism; ATP-binding cassette transporter; Transporter; In vitro; Biology; Microsome; Enzyme; Leukotriene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200644,0.0004208329,0.0003546963,0.0001659907,0.0001681856,0.0004811516,0.0001758649,0.0003831077,0.0007413688],"category_scores_gemma":[0.0001023737,0.0001798158,0.0003044376,0.0001319811,0.0001887962,0.0003930192,0.0001559693,0.0004052812,0.0004406592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000479512,"about_ca_system_score_gemma":0.000300347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002318632,"about_ca_topic_score_gemma":0.001832636,"domain_scores_codex":[0.9998947,0.00001900515,0.000006583545,0.00003642694,0.00002464126,0.00001864686],"domain_scores_gemma":[0.9999287,0.0000134035,0.00002153473,0.000007242974,0.00001774668,0.00001123975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004529542,0.000009884145,0.0005684509,0.00004780465,0.00001424254,0.00005461014,0.00003205953,0.00007230723,0.9972492,0.0001781709,0.00003058161,0.001697284],"study_design_scores_gemma":[0.00001304946,0.0003645522,0.01112267,0.00001211205,0.00005316399,0.0006262483,0.0001322058,0.002532875,0.9803174,0.0001234155,0.004691153,0.00001112041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921085,0.00364285,0.002907292,0.0001612627,0.00002881325,0.00002691849,0.0002341204,0.00004544144,0.0008446333],"genre_scores_gemma":[0.9917392,0.00221428,0.002125154,0.00004187785,0.000008333454,0.0000121426,0.0006462264,0.00002573547,0.003187057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318632,"threshold_uncertainty_score":0.00461024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774008556070168,"score_gpt":0.2254376353451178,"score_spread":0.2076975497844161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}