{"id":"W2099989980","doi":"10.1093/hmg/ddr270","title":"Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration","year":2011,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Alcon Research Institute; National Eye Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Tufts University School of Medicine; Medical Research Council; National Institutes of Health; National Health and Medical Research Council; National Institute of Mental Health; Northwestern University; State Government of Victoria; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation; Tufts Medical Center; Brigham and Women's Hospital; Research to Prevent Blindness","keywords":"Biology; Genetics; Single-nucleotide polymorphism; Genome-wide association study; Macular degeneration; Genotype; Locus (genetics); Genetic association; Allele; 1000 Genomes Project; Gene; Ophthalmology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001555199,0.0008313099,0.0009087593,0.001620356,0.0004531494,0.0008350847,0.0006960572,0.0007131056,0.002247127],"category_scores_gemma":[0.003838257,0.0003918449,0.002185767,0.002551351,0.000416168,0.0002092537,0.0005264906,0.0006618044,0.0001740499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004186384,"about_ca_system_score_gemma":0.0003542779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009808321,"about_ca_topic_score_gemma":0.01088302,"domain_scores_codex":[0.9987735,0.0002835343,0.0001263335,0.0004732686,0.0002168108,0.0001264765],"domain_scores_gemma":[0.997638,0.0009951174,0.0007586657,0.0003184674,0.0001439286,0.0001458874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002707164,0.00007711823,0.9560167,0.0002428801,0.01014693,0.001930883,0.0001549634,0.001239508,0.01590903,0.0001504047,0.0006645519,0.0107599],"study_design_scores_gemma":[0.0001384296,0.0001112799,0.9918321,0.00003357947,0.003437521,0.001201812,0.00006429179,0.001114866,0.001113102,0.0002730847,0.0006650952,0.00001488599],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9908293,0.005626335,0.001346847,0.0001880242,0.00004281423,0.00001753512,0.001346038,0.00005084024,0.0005521375],"genre_scores_gemma":[0.9978174,0.0007981978,0.0005745805,0.00004775286,0.00004019235,0.00001126357,0.0004978944,0.00001178722,0.0002009591],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009808321,"threshold_uncertainty_score":0.01950246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03624401446151436,"score_gpt":0.315087289853787,"score_spread":0.2788432753922726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}