{"id":"W2100062934","doi":"10.1039/b606914b","title":"γ-Glutamyl transpeptidase acylation with peptidic substrates: free energy relationships measured by an HPLC kinetic assay","year":2006,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Acylation; Glutathione; Substrate (aquarium); Enzyme; Hydrolysis; Amino acid; Stereochemistry; Chromogenic; Chromatography; Amine gas treating; Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003376741,0.0005039074,0.0002982187,0.00004854538,0.000223523,0.00007875182,0.0006778984,0.0006528422,0.0002057528],"category_scores_gemma":[0.0001220215,0.0005003984,0.0001316055,0.0003800853,0.0003049497,0.00001733505,0.00008086373,0.000283635,0.00001406498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008279009,"about_ca_system_score_gemma":0.0001988537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001049481,"about_ca_topic_score_gemma":0.0001680997,"domain_scores_codex":[0.9973257,0.0002552002,0.0004736136,0.001003212,0.0003750641,0.0005671637],"domain_scores_gemma":[0.9979877,0.00003018692,0.0002151705,0.001342686,0.0002082512,0.0002159521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001157717,0.0002460476,0.00174993,0.00002951493,0.00008546135,0.00003000259,0.00001805114,0.0000147115,0.9957688,0.00003720347,0.001751356,0.000153193],"study_design_scores_gemma":[0.001417352,0.0002440633,0.001054383,0.00002499057,0.00008906342,0.0002071581,0.00005268228,0.0001172869,0.9891244,0.0003955147,0.006618571,0.0006545542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7782379,0.001633798,0.2159177,0.0002687344,0.00007389146,0.000197584,0.0001107035,0.0001433059,0.003416429],"genre_scores_gemma":[0.9928911,0.0000508437,0.001426491,0.0001210784,0.0003411654,0.00004218491,0.003931679,0.0001243953,0.001071095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2146532,"threshold_uncertainty_score":0.9997448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008463528977962828,"score_gpt":0.2020770231338002,"score_spread":0.1936134941558373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}