{"id":"W2100085143","doi":"10.2337/db10-0627","title":"Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Insulin; Adipose tissue; Methylglyoxal; Glucose tolerance test; Diabetes mellitus; Pancreatic islets; Glucokinase; Biology; Chemistry; Medicine; Insulin resistance; Islet; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533977,0.0001713712,0.0001734865,0.00009262605,0.0000591084,0.00002092578,0.0001310751,0.0001442,0.00007248032],"category_scores_gemma":[0.0003023783,0.0001595955,0.00002372234,0.0002112511,0.0001117823,0.00002125401,0.000121525,0.0001362848,0.00002241409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002871983,"about_ca_system_score_gemma":0.00007757715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003549406,"about_ca_topic_score_gemma":0.00002816833,"domain_scores_codex":[0.998741,0.0001255686,0.0001944756,0.0004237295,0.000126226,0.000389054],"domain_scores_gemma":[0.9994066,0.0000462888,0.00007416783,0.0002880471,0.00009392043,0.00009093129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001879336,0.00005127889,0.06987685,0.00006438507,0.00001921412,5.15408e-7,0.00007274153,0.00000354953,0.9241005,0.000005792167,0.0004371549,0.005349185],"study_design_scores_gemma":[0.0003721681,0.000501155,0.01357796,0.00002355827,0.00001335552,2.094536e-7,0.00005634139,0.00003338062,0.9804823,0.0001194985,0.004627101,0.000192947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878357,0.01120524,0.000009497626,0.00005572604,0.0001332172,0.0002199962,0.00001135975,0.00001638218,0.0005128604],"genre_scores_gemma":[0.9974421,0.001358883,0.0002851801,0.00007845595,0.0001423437,0.00004341029,0.0001704634,0.00002715742,0.0004519821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05638178,"threshold_uncertainty_score":0.6508116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875093334277791,"score_gpt":0.2611635092106235,"score_spread":0.2424125758678456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}