{"id":"W2100100178","doi":"10.1158/1078-0432.ccr-05-2152","title":"Phase 1 and Pharmacokinetic Study of Intravenous Irinotecan in Refractory Solid Tumor Patients with Hepatic Dysfunction","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"National Center for Research Resources","keywords":"Medicine; Irinotecan; Bilirubin; Gastroenterology; Internal medicine; Pharmacokinetics; Neutropenia; Liver function; Nausea; Vomiting; Adverse effect; Jaundice; Liver function tests; Alanine transaminase; Toxicity; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000578897,0.0009637268,0.001467211,0.0002279605,0.0003666946,0.0004402519,0.0004238516,0.0004709615,0.001336483],"category_scores_gemma":[0.0008614381,0.0003363207,0.0004474967,0.0002913956,0.0006282919,0.0004283465,0.0001817452,0.001544793,0.0003876372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006573293,"about_ca_system_score_gemma":0.001600749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006221146,"about_ca_topic_score_gemma":0.001232667,"domain_scores_codex":[0.9996927,0.0001486993,0.00001287056,0.0000414736,0.00003973026,0.00006462384],"domain_scores_gemma":[0.9995257,0.0001034427,0.000113731,0.00003938845,0.00002910067,0.0001887891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3794557,0.0993136,0.05140075,0.0006544421,0.0008971408,0.001313654,0.0007563211,0.01419003,0.2200149,0.0003949997,0.004565593,0.2270429],"study_design_scores_gemma":[0.1980558,0.6946637,0.06250625,0.00004668953,0.0004877271,0.001477489,0.0001315377,0.007142139,0.0296073,0.0002940837,0.005527795,0.00005958415],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984241,0.0004537035,0.0002924063,0.0000772192,0.00001198359,0.0002541791,0.000105915,0.00002290244,0.0003575231],"genre_scores_gemma":[0.9960759,0.0005006866,0.001263276,0.0002131568,0.0000427403,0.0005203649,0.0007497958,0.00001365676,0.0006203778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467211,"threshold_uncertainty_score":0.004769325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06193093059145054,"score_gpt":0.4521873401978237,"score_spread":0.3902564096063731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}