{"id":"W2100100178","doi":"10.1158/1078-0432.ccr-05-2152","title":"Phase 1 and Pharmacokinetic Study of Intravenous Irinotecan in Refractory Solid Tumor Patients with Hepatic Dysfunction","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"National Center for Research Resources","keywords":"Medicine; Irinotecan; Bilirubin; Gastroenterology; Internal medicine; Pharmacokinetics; Neutropenia; Liver function; Nausea; Vomiting; Adverse effect; Jaundice; Liver function tests; Alanine transaminase; Toxicity; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005986003,0.0001018297,0.000204037,0.00008375532,0.00004733719,0.00001251469,0.0001173963,0.00006455242,0.00002635189],"category_scores_gemma":[0.00003263149,0.00008569552,0.00002687784,0.0001643428,0.0001600363,0.000003576962,0.00008548894,0.0002732604,7.883565e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005352572,"about_ca_system_score_gemma":0.0002053232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340705,"about_ca_topic_score_gemma":0.002146438,"domain_scores_codex":[0.9985076,0.0001879129,0.0003769393,0.0003688222,0.0002992518,0.0002594562],"domain_scores_gemma":[0.9993484,0.00004069152,0.00008988968,0.0002296091,0.0002146685,0.00007672886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01912745,0.05355405,0.2316399,0.0003370603,0.0003559194,0.00006226735,0.0005903718,0.0006356679,0.4177302,0.00007103261,0.0003440904,0.2755519],"study_design_scores_gemma":[0.113916,0.1552939,0.527043,0.0003455003,0.0002093798,0.00000549898,0.001073597,0.0004469969,0.1868827,0.0008883988,0.01287658,0.001018354],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986613,0.0004316033,0.00005277973,0.00003151514,0.0001087119,0.000615617,0.0000211492,0.000003461908,0.00007390385],"genre_scores_gemma":[0.9992903,0.0002620102,0.00001916932,0.00005383505,0.0001783172,0.0001022542,0.00002257888,0.00002105732,0.00005046971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2954032,"threshold_uncertainty_score":0.3494562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06193093059145054,"score_gpt":0.4521873401978237,"score_spread":0.3902564096063731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}